Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 17. Structure−Activity Relationships of Several Series of Compounds Derived from N-Chlorosulfonyl Isocyanate

Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3−44 were the most potent inhibitors in vitro, with several compounds having IC50 values &l...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-03, Vol.39 (6), p.1243-1252
Hauptverfasser:	Picard, Joseph A, O'Brien, Patrick M, Sliskovic, Drago R, Anderson, Maureen K, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme Inhibitors - pharmacology Isocyanates - pharmacology Rats Sterol O-Acyltransferase - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
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