P-selectin mediates intestinal ischemic injury by enhancing complement deposition

Background. Ischemia and reperfusion injury of rodent intestine is complement mediated. P-seletin antagonism reduces local injury, yet neutrophil depletion does not. This study tests the thesis that the protective mechanism of P-selectin antagonists involves complement inhibition. Methods. We subjec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Surgery 1996-06, Vol.119 (6), p.652-656
Hauptverfasser:	Gibbs, Simon A.L., Weiser, Martin R., Kobzik, Lester, Valeri, C. Robert, Shepro, David, Hechtman, Herbert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Biological and medical sciences Complement Membrane Attack Complex - physiology Gastroenterology. Liver. Pancreas. Abdomen Intestines - blood supply Ischemia - metabolism Male Medical sciences Neutrophils - physiology Other diseases. Semiology P-Selectin - physiology Permeability Peroxidase - metabolism Rats Rats, Sprague-Dawley Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!