Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods

Assays for tumor mutations need to be sufficiently sensitive that a mutation can be readily detected in a high background of wild-type sequence. We have evaluated competitive allele-specific oligonucleotide (cASO) hybridization, the amplification refractory mutation system (ARMS), and a combination...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 1996-06, Vol.42 (6), p.904-909
Hauptverfasser:	Carpenter, KM, Durrant, LG, Morgan, K, Bennett, D, Hardcastle, JD, Kalsheker, NA
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Colorectal Neoplasms - genetics DNA Mutational Analysis - methods Gastroenterology. Liver. Pancreas. Abdomen Genes, ras Humans Medical sciences Molecular Sequence Data Mutation Nucleic Acid Hybridization Polymerase Chain Reaction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Valine - genetics
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