Chronic meningococcemia and IgA deficiency in an adolescent
Chronic meningococcemia, defined as a meningococcal septicemia without meningeal symptoms with persistence of fever for at least one week prior to any antibiotics, is uncommon. Its pathophysiology remains unclear and a defect in host immunity has been suggested. A 15 year-old adolescent was examined...
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| Veröffentlicht in: | Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1996-02, Vol.3 (2), p.149-151 |
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| container_title | Archives de pédiatrie : organe officiel de la Société française de pédiatrie |
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| creator | Farron, F Cheseaux, J J Pelet, B |
| description | Chronic meningococcemia, defined as a meningococcal septicemia without meningeal symptoms with persistence of fever for at least one week prior to any antibiotics, is uncommon. Its pathophysiology remains unclear and a defect in host immunity has been suggested.
A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
This is the first reported case in which chronic meningococcemia is associated with complete IgA deficiency. |
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A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
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A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
This is the first reported case in which chronic meningococcemia is associated with complete IgA deficiency.</description><subject>Adolescent</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Cephalosporins - therapeutic use</subject><subject>Chronic Disease</subject><subject>Humans</subject><subject>IgA Deficiency - complications</subject><subject>Male</subject><subject>Meningococcal Infections - complications</subject><subject>Meningococcal Infections - drug therapy</subject><subject>Meningococcal Infections - immunology</subject><subject>Penicillins - therapeutic use</subject><issn>0929-693X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj71qwzAYRTW0pGnaRyho6mbQjy1_olMw_QkEumToZmTpc6piSa4VD3n7GurpwuVwD_eGbJkWulBaft2R-5x_GGPAQG7IBmqoKllvyUvzPaXoLQ0YfTwnm6zF4A010dHDeU8d9t56jPZKfVxaalwaMFuMlwdy25sh4-OaO3J6ez01H8Xx8_3Q7I_FuCiKUiB22vSlM5ZrsIIDCMcM01BL4EYLhUJ0TAErK1X2Sndc1qKCUrGKayl35Pl_dpzS74z50ga_-IfBRExzbmtgmistFvBpBecuoGvHyQczXdv1rPwDNPZNOQ</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>Farron, F</creator><creator>Cheseaux, J J</creator><creator>Pelet, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>Chronic meningococcemia and IgA deficiency in an adolescent</title><author>Farron, F ; Cheseaux, J J ; Pelet, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p537-42eeb9af4dac198c21882d0a0987381a926e22b06804564f69b13725846051933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Cephalosporins - therapeutic use</topic><topic>Chronic Disease</topic><topic>Humans</topic><topic>IgA Deficiency - complications</topic><topic>Male</topic><topic>Meningococcal Infections - complications</topic><topic>Meningococcal Infections - drug therapy</topic><topic>Meningococcal Infections - immunology</topic><topic>Penicillins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farron, F</creatorcontrib><creatorcontrib>Cheseaux, J J</creatorcontrib><creatorcontrib>Pelet, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farron, F</au><au>Cheseaux, J J</au><au>Pelet, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic meningococcemia and IgA deficiency in an adolescent</atitle><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle><addtitle>Arch Pediatr</addtitle><date>1996-02</date><risdate>1996</risdate><volume>3</volume><issue>2</issue><spage>149</spage><epage>151</epage><pages>149-151</pages><issn>0929-693X</issn><abstract>Chronic meningococcemia, defined as a meningococcal septicemia without meningeal symptoms with persistence of fever for at least one week prior to any antibiotics, is uncommon. Its pathophysiology remains unclear and a defect in host immunity has been suggested.
A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
This is the first reported case in which chronic meningococcemia is associated with complete IgA deficiency.</abstract><cop>France</cop><pmid>8785537</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0929-693X |
| ispartof | Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 1996-02, Vol.3 (2), p.149-151 |
| issn | 0929-693X |
| language | fre |
| recordid | cdi_proquest_miscellaneous_78091692 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Ceftriaxone - therapeutic use Cephalosporins - therapeutic use Chronic Disease Humans IgA Deficiency - complications Male Meningococcal Infections - complications Meningococcal Infections - drug therapy Meningococcal Infections - immunology Penicillins - therapeutic use |
| title | Chronic meningococcemia and IgA deficiency in an adolescent |
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