Target Cell-Induced Apoptosis of Interleukin-2–Activated Human Natural Killer Cells: Roles of Cell Surface Molecules and Intracellular Events

We previously reported that natural killer (NK)-sensitive target cells, K562, kill interleukin-2-stimulated (lymphokine-activated killer [LAK]) but not unstimulated NK cells. We have now investigated the molecular basis of this phenomenon. Soluble monoclonal antibody (MoAb) to CD18 inhibited 75% of...

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Veröffentlicht in:	Blood 1996-06, Vol.87 (12), p.5127-5135
Hauptverfasser:	Yamauchi, Akira, Taga, Kazuyuki, Mostowski, Howard S., Bloom, Eda T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antigens, CD - immunology Antigens, CD - physiology Apoptosis - drug effects Benzoquinones Biological and medical sciences CD18 Antigens - immunology CD18 Antigens - physiology Cell Membrane - ultrastructure Cell physiology Cysteine Endopeptidases - metabolism Cytotoxicity, Immunologic DNA - analysis Fas Ligand Protein fas Receptor - physiology Fundamental and applied biological sciences. Psychology Humans Interleukin-2 - pharmacology Killer Cells, Lymphokine-Activated - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lactams, Macrocyclic Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymphoma, Non-Hodgkin - pathology Melanoma - pathology Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Molecular and cellular biology Protease Inhibitors - pharmacology Quinones - pharmacology Recombinant Fusion Proteins - metabolism Rifabutin - analogs & derivatives Serine Endopeptidases - metabolism Transfection Tumor Cells, Cultured
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