S-adenosyl-L-methionine protects the hippocampal CA1 neurons from the ischemic neuronal death in rat

We investigated the effect of S-adenosyl-L-methionine (SAMe) on the prevention of the delayed neuronal death in rats subjected to transient and brief forebrain ischemia. As the results, SAMe dose-dependently protected the hippocampal CA1 neurons from degeneration and necrosis, whose effect was suppr...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-01, Vol.150 (1), p.491-496
Hauptverfasser:	Sato, Hiromi, Hariyama, Hisayo, Moriguchi, Koei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Membrane - pathology Cell Survival - drug effects Cytidine Diphosphate Choline - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus - pathology Ischemic Attack, Transient - pathology Isolated neuron and nerve. Neuroglia Male Methionine - pharmacology Methylation Necrosis Nerve Degeneration - drug effects Neurons - pathology Phosphatidylcholines - pharmacology Rats Rats, Inbred Strains S-Adenosylhomocysteine - pharmacology S-Adenosylmethionine - pharmacology Vertebrates: nervous system and sense organs
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