Benzodiazepine binding sites in rat interscapular brown adipose tissue: Effect of cold environment, denervation and endocrine ablations

3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (K D) = 0.47 ± 0.04 um and maximal number of binding sites (B max) = 31 ± 5 pmol.mg prot...

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Veröffentlicht in:	Life Sci.; (United States) 1988, Vol.42 (4), p.393-402
Hauptverfasser:	Gonzalez Solveyra, C., Romeo, H.E., Rosenstein, Ruth E., Estevez, A.G., Cardinali, D.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ADIPOSE TISSUE adipose tissue (brown) Adipose Tissue - metabolism AMINE OXIDASES ANIMAL TISSUES ANIMALS BASIC BIOLOGICAL SCIENCES benzodiazepines BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY BODY TEMPERATURE CELL CONSTITUENTS Cell Membrane - metabolism CELL MEMBRANES CENTRAL NERVOUS SYSTEM CENTRAL NERVOUS SYSTEM AGENTS Cold Temperature CONNECTIVE TISSUE DATA Denervation DRUGS ENDOCRINE GLANDS Endocrine Glands - physiology ENZYME ACTIVITY ENZYMES EXPERIMENTAL DATA Female Flunitrazepam - metabolism General pharmacology GLANDS Hypophysectomy HYPOTHERMIA INFORMATION KINETICS MAMMALS Medical sciences MEMBRANE PROTEINS MEMBRANES MITOCHONDRIA Mitochondria - metabolism NERVOUS SYSTEM NUMERICAL DATA ORGANIC COMPOUNDS ORGANOIDS ORGANS OXIDOREDUCTASES Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments PROTEINS PSYCHOTROPIC DRUGS RATS Rats, Inbred Strains REACTION KINETICS RECEPTORS Receptors, GABA-A - metabolism RESPONSE MODIFYING FACTORS RODENTS Sympathetic Nervous System - physiology TISSUES TRANQUILIZERS VERTEBRATES
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