Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70
CD27, which belongs to the tumor necrosis‐factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed...
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| Veröffentlicht in: | European journal of immunology 1996-05, Vol.26 (5), p.1007-1011 |
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| container_title | European journal of immunology |
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| creator | Lens, Susanne M. A. Keehnen, Robert M. J. van Oers, Marinus H. J. van Lier, René A. W. Pals, Steven T. Koopman, Gerrit |
| description | CD27, which belongs to the tumor necrosis‐factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD−, CD38− B cell population, which have been described as memory B cells. However, in 10 % of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10− and CD38−, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation. |
| doi_str_mv | 10.1002/eji.1830260508 |
| format | Article |
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A. ; Keehnen, Robert M. J. ; van Oers, Marinus H. J. ; van Lier, René A. W. ; Pals, Steven T. ; Koopman, Gerrit</creator><creatorcontrib>Lens, Susanne M. A. ; Keehnen, Robert M. J. ; van Oers, Marinus H. J. ; van Lier, René A. W. ; Pals, Steven T. ; Koopman, Gerrit</creatorcontrib><description>CD27, which belongs to the tumor necrosis‐factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD−, CD38− B cell population, which have been described as memory B cells. However, in 10 % of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10− and CD38−, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830260508</identifier><identifier>PMID: 8647160</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Antigens, CD - biosynthesis ; B cell subpopulation ; B-Lymphocyte Subsets - classification ; B-Lymphocyte Subsets - immunology ; B-Lymphocyte Subsets - metabolism ; CD27 Ligand ; CD70 ; Cell Differentiation - immunology ; Child ; Child, Preschool ; Flow Cytometry ; Germinal center ; Germinal Center - cytology ; Germinal Center - immunology ; Humans ; Immunoglobulin D - biosynthesis ; Infant ; Membrane Proteins - biosynthesis ; Palatine Tonsil - immunology ; Palatine Tonsil - metabolism</subject><ispartof>European journal of immunology, 1996-05, Vol.26 (5), p.1007-1011</ispartof><rights>Copyright © 1996 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3718-b688e04e82f624001cb09ce49cbd275558c0509b98319c5c322f26491f8f631b3</citedby><cites>FETCH-LOGICAL-c3718-b688e04e82f624001cb09ce49cbd275558c0509b98319c5c322f26491f8f631b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830260508$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830260508$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8647160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lens, Susanne M. A.</creatorcontrib><creatorcontrib>Keehnen, Robert M. J.</creatorcontrib><creatorcontrib>van Oers, Marinus H. J.</creatorcontrib><creatorcontrib>van Lier, René A. W.</creatorcontrib><creatorcontrib>Pals, Steven T.</creatorcontrib><creatorcontrib>Koopman, Gerrit</creatorcontrib><title>Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>CD27, which belongs to the tumor necrosis‐factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD−, CD38− B cell population, which have been described as memory B cells. However, in 10 % of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10− and CD38−, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation.</description><subject>Antigens, CD - biosynthesis</subject><subject>B cell subpopulation</subject><subject>B-Lymphocyte Subsets - classification</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocyte Subsets - metabolism</subject><subject>CD27 Ligand</subject><subject>CD70</subject><subject>Cell Differentiation - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Flow Cytometry</subject><subject>Germinal center</subject><subject>Germinal Center - cytology</subject><subject>Germinal Center - immunology</subject><subject>Humans</subject><subject>Immunoglobulin D - biosynthesis</subject><subject>Infant</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Palatine Tonsil - immunology</subject><subject>Palatine Tonsil - metabolism</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFv2zAQhYkiheOkXbMF4JRN7pEiKXJM7LRxEaBLOwsUdXJpyJJCWkncX18GFtxumUjwvffhjo-QKwYLBsC_4NYvmM6BK5CgP5A5k5xlggl2RuYATGTcaDgnFzFuAcAoaWZkppUomII56dY1dnvfeGf3vu9o31BLu_4ZWxrHauiHsT0JGww739mWuhTBQO_SpW0jdb9tsC69-D9Y0-pA8XUIGOMUW29W1HY1Xa4K-EQ-NraN-Hk6L8mvr_c_lw_Z449v6-XtY-bygumsUlojCNS8UVykLVwFxqEwrqp5IaXULm1rKqNzZpx0OecNV8KwRjcqZ1V-SW6O3CH0TyPGfbnz8W1a22E_xrLQoCUo-a6RSSUSvUjGxdHoQh9jwKYcgt_ZcCgZlG9NlKmJ8l8TKXA9kcdqh_XJPn190s1Rf_EtHt6hlfff1_-x_wImR5OF</recordid><startdate>199605</startdate><enddate>199605</enddate><creator>Lens, Susanne M. A.</creator><creator>Keehnen, Robert M. J.</creator><creator>van Oers, Marinus H. J.</creator><creator>van Lier, René A. W.</creator><creator>Pals, Steven T.</creator><creator>Koopman, Gerrit</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199605</creationdate><title>Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70</title><author>Lens, Susanne M. A. ; Keehnen, Robert M. J. ; van Oers, Marinus H. J. ; van Lier, René A. W. ; Pals, Steven T. ; Koopman, Gerrit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3718-b688e04e82f624001cb09ce49cbd275558c0509b98319c5c322f26491f8f631b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antigens, CD - biosynthesis</topic><topic>B cell subpopulation</topic><topic>B-Lymphocyte Subsets - classification</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocyte Subsets - metabolism</topic><topic>CD27 Ligand</topic><topic>CD70</topic><topic>Cell Differentiation - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Flow Cytometry</topic><topic>Germinal center</topic><topic>Germinal Center - cytology</topic><topic>Germinal Center - immunology</topic><topic>Humans</topic><topic>Immunoglobulin D - biosynthesis</topic><topic>Infant</topic><topic>Membrane Proteins - biosynthesis</topic><topic>Palatine Tonsil - immunology</topic><topic>Palatine Tonsil - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lens, Susanne M. A.</creatorcontrib><creatorcontrib>Keehnen, Robert M. J.</creatorcontrib><creatorcontrib>van Oers, Marinus H. J.</creatorcontrib><creatorcontrib>van Lier, René A. W.</creatorcontrib><creatorcontrib>Pals, Steven T.</creatorcontrib><creatorcontrib>Koopman, Gerrit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lens, Susanne M. A.</au><au>Keehnen, Robert M. J.</au><au>van Oers, Marinus H. J.</au><au>van Lier, René A. W.</au><au>Pals, Steven T.</au><au>Koopman, Gerrit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1996-05</date><risdate>1996</risdate><volume>26</volume><issue>5</issue><spage>1007</spage><epage>1011</epage><pages>1007-1011</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>CD27, which belongs to the tumor necrosis‐factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD−, CD38− B cell population, which have been described as memory B cells. However, in 10 % of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10− and CD38−, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>8647160</pmid><doi>10.1002/eji.1830260508</doi><tpages>5</tpages></addata></record> |
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| subjects | Antigens, CD - biosynthesis B cell subpopulation B-Lymphocyte Subsets - classification B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism CD27 Ligand CD70 Cell Differentiation - immunology Child Child, Preschool Flow Cytometry Germinal center Germinal Center - cytology Germinal Center - immunology Humans Immunoglobulin D - biosynthesis Infant Membrane Proteins - biosynthesis Palatine Tonsil - immunology Palatine Tonsil - metabolism |
| title | Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70 |
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