Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions
ABSTRACT We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge. Premature infants who were transfused with more than 100 ml pa...
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| Veröffentlicht in: | American journal of perinatology 1988-01, Vol.5 (1), p.40-43 |
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| container_title | American journal of perinatology |
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| creator | Arad, Ilan Konijn, Avraham M. Linder, Nechama Goldstein, Mara Kaufmann, Nathan A. |
| description | ABSTRACT
We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge.
Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively).
At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 μg/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 μg/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 μg/L) or group C who received less than 100 ml (36.5 ± 8.8 μg/L packed red blood cells. However, these differences were not statistically significant.
Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life.
Administration of large amounts of supplemental iron, in such cases, may be curtailed. |
| doi_str_mv | 10.1055/s-2007-999651 |
| format | Article |
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We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge.
Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively).
At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 μg/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 μg/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 μg/L) or group C who received less than 100 ml (36.5 ± 8.8 μg/L packed red blood cells. However, these differences were not statistically significant.
Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life.
Administration of large amounts of supplemental iron, in such cases, may be curtailed.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-999651</identifier><identifier>PMID: 3337757</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Anemia, Hypochromic - prevention & control ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Transfusion ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Ferritins - blood ; Follow-Up Studies ; Humans ; Infant ; Infant Food ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature - blood ; Intensive care medicine ; Medical sciences ; ORIGINAL ARTICLE</subject><ispartof>American journal of perinatology, 1988-01, Vol.5 (1), p.40-43</ispartof><rights>1988 by Thieme Medical Publishers, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-abe49366ee33cfce34511346d8d07db8cdc31d586b0f09c317b6f203d7ae818a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-999651.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-999651$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,4024,27923,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7031254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3337757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arad, Ilan</creatorcontrib><creatorcontrib>Konijn, Avraham M.</creatorcontrib><creatorcontrib>Linder, Nechama</creatorcontrib><creatorcontrib>Goldstein, Mara</creatorcontrib><creatorcontrib>Kaufmann, Nathan A.</creatorcontrib><title>Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge.
Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively).
At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 μg/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 μg/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 μg/L) or group C who received less than 100 ml (36.5 ± 8.8 μg/L packed red blood cells. However, these differences were not statistically significant.
Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life.
Administration of large amounts of supplemental iron, in such cases, may be curtailed.</description><subject>Anemia, Hypochromic - prevention & control</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Ferritins - blood</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Food</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>ORIGINAL ARTICLE</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMo67p69Cj0IJ6sJk3TpEddXF1ZUXA9hzSdYKUfa6YV_Pdm2bI3TzPD-zDDPIScM3rDqBC3GCeUyjjP80ywAzJlNFexkkockimVXMQs4-yYnCB-UcoSRdWETDjnUgo5Jc_v4IcmWoD3VV-10Qp-oMYodG8eevBNtGydaXuMjAtj9DLUfbWpIbqvu66M1t606AasuhZPyZEzNcLZWGfkY_Gwnj_Fq9fH5fxuFVsu0j42BaQ5zzIAzq2zwFPBGE-zUpVUloWypeWsFCorqKN56GWRuYTyUhpQTBk-I1e7vRvffQ-AvW4qtFDXpoVuQC3Di2mWigDGO9D6DtGD0xtfNcb_akb11p1GvXWnd-4CfzEuHooGyj09ygr55ZgbtKZ24Xdb4R6TlLNEpAG73mH9ZwUN6K9u8G0Q8s_VP2QxhDw</recordid><startdate>198801</startdate><enddate>198801</enddate><creator>Arad, Ilan</creator><creator>Konijn, Avraham M.</creator><creator>Linder, Nechama</creator><creator>Goldstein, Mara</creator><creator>Kaufmann, Nathan A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198801</creationdate><title>Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions</title><author>Arad, Ilan ; Konijn, Avraham M. ; Linder, Nechama ; Goldstein, Mara ; Kaufmann, Nathan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-abe49366ee33cfce34511346d8d07db8cdc31d586b0f09c317b6f203d7ae818a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anemia, Hypochromic - prevention & control</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Ferritins - blood</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>ORIGINAL ARTICLE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arad, Ilan</creatorcontrib><creatorcontrib>Konijn, Avraham M.</creatorcontrib><creatorcontrib>Linder, Nechama</creatorcontrib><creatorcontrib>Goldstein, Mara</creatorcontrib><creatorcontrib>Kaufmann, Nathan A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arad, Ilan</au><au>Konijn, Avraham M.</au><au>Linder, Nechama</au><au>Goldstein, Mara</au><au>Kaufmann, Nathan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1988-01</date><risdate>1988</risdate><volume>5</volume><issue>1</issue><spage>40</spage><epage>43</epage><pages>40-43</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge.
Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively).
At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 μg/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 μg/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 μg/L) or group C who received less than 100 ml (36.5 ± 8.8 μg/L packed red blood cells. However, these differences were not statistically significant.
Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life.
Administration of large amounts of supplemental iron, in such cases, may be curtailed.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>3337757</pmid><doi>10.1055/s-2007-999651</doi><tpages>4</tpages></addata></record> |
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| subjects | Anemia, Hypochromic - prevention & control Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Transfusion Emergency and intensive care: neonates and children. Prematurity. Sudden death Ferritins - blood Follow-Up Studies Humans Infant Infant Food Infant, Low Birth Weight Infant, Newborn Infant, Premature - blood Intensive care medicine Medical sciences ORIGINAL ARTICLE |
| title | Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions |
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