Irreversible inhibition of the TXA2/PGH2 receptor of human platelets by a photoaffinity ligand

In order to tag the TXA2/PGH2 receptor of human platelets, we synthesized azido-BSP (= 4-[2-(4-azido-benzenesulfonylamino)-ethyl]phenoxyacetic acid), a photolabile derivative of the specific TXA2/PGH2 receptor antagonist sulotroban (= BM 13.177). If protected from UV light, azido-BSP competitively i...

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Veröffentlicht in:	Biochemical pharmacology 1988-02, Vol.37 (3), p.491-495
Hauptverfasser:	ZEHENDER, H, WITTE, E.-C, WOLFF, H.-P, PATSCHEKE, H
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Affinity Labels - pharmacology Applied sciences Azides - pharmacology Biological and medical sciences Blood Platelets - metabolism Exact sciences and technology Fibrinolytic Agents - pharmacology Fundamental and applied biological sciences. Psychology Humans Kinetics Other techniques and industries Prostaglandin Endoperoxides - metabolism Prostaglandin Endoperoxides, Synthetic - metabolism Prostaglandin Endoperoxides, Synthetic - pharmacology Prostaglandin H2 Prostaglandins H - metabolism Prostaglandins. Arachidonic acid metabolites Receptors, Prostaglandin - drug effects Receptors, Prostaglandin - metabolism Receptors, Thromboxane Sulfonamides - pharmacology Thromboxane A2 - blood Vertebrates: endocrinology
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