Recognition of out‐of‐frame major histocompatibility complex class I‐restricted epitopes in vivo

In the course of constructing a recombinant vaccinia virus encoding the influenza A nucleoprotein (NP) gene preceeded by the hemagglutinin leader sequence, we isolated a single base‐pair deletion mutant which gave rise to L+NP(1–159) in which only the first 159 amino acids were in frame. Despite thi...

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