Synthesis and pharmacological activity of N-alkyl-1,2-diphenylethanolamines

A series of N-alkyl-1,2-diphenylethanolamines were synthesized and their pharmacological activities evaluated on various mammalian organs and systems. All compounds produced a generalized inhibitory effect on smooth and cardiac muscles and an increase in coronary flow as well as a brief reduction in...

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Veröffentlicht in:	Pharmaceutical research 1987-04, Vol.4 (2), p.166-170
Hauptverfasser:	EL-OBEID, H. A, MADANI, A. A. E, AL-RASHOOD, K. A, EL TAHIR, K. E. H, ABDUL KARIM TILMISANI, IBRAHIM, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents Atropine - pharmacology Biological and medical sciences Blood Pressure - drug effects Calcium Channel Blockers Coronary Circulation - drug effects Ethanolamines - antagonists & inhibitors Ethanolamines - chemical synthesis Ethanolamines - pharmacology General pharmacology Jejunum - drug effects Male Medical sciences Metoprolol - pharmacology Muscle, Smooth, Vascular - drug effects Myocardial Contraction - drug effects Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Propranolol - pharmacology Rabbits Rats Vas Deferens - drug effects
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