Antioxidant depletion during aortic aneurysm repair
Ischaemia–reperfusion injury generates oxygen‐derived free radicals leading to local and distant damage. A simple method of following oxidative activity is to measure the consumption of endogenous scavenging antioxidants; an enhanced chemiluminescent assay was used to study this phenomenon in 21 pat...
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| Veröffentlicht in: | British journal of surgery 1996-03, Vol.83 (3), p.401-403 |
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| container_title | British journal of surgery |
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| creator | Khaira, H. S. Maxwell, S. R. J. Thomason, H. Thorpe, G. H. G. Green, M. A. Shearman, C. P. |
| description | Ischaemia–reperfusion injury generates oxygen‐derived free radicals leading to local and distant damage. A simple method of following oxidative activity is to measure the consumption of endogenous scavenging antioxidants; an enhanced chemiluminescent assay was used to study this phenomenon in 21 patients undergoing surgery for abdominal aortic aneurysm (AAA). Samples of peripheral venous blood were taken before induction of anaesthesia and then from a central venous line and the inferior mesenteric vein before, during, and after clamping of the aorta. Further specimens were taken from the central line at 2, 6 and 24 h after operation. Antioxidant concentration in the peripheral, central and inferior mesenteric blood were similar, indicating that anaesthesia and surgical dissection had no effect. Levels decreased significantly in central and inferior mesenteric blood during and after clamping, but returned to normal by 24 h. These results confirm ischaemia‐reperfusion phenomena in AAA repair. |
| doi_str_mv | 10.1002/bjs.1800830335 |
| format | Article |
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Antioxidant concentration in the peripheral, central and inferior mesenteric blood were similar, indicating that anaesthesia and surgical dissection had no effect. Levels decreased significantly in central and inferior mesenteric blood during and after clamping, but returned to normal by 24 h. These results confirm ischaemia‐reperfusion phenomena in AAA repair.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800830335</identifier><identifier>PMID: 8665207</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Aged ; Aged, 80 and over ; Antioxidants - metabolism ; Aortic Aneurysm, Abdominal - metabolism ; Aortic Aneurysm, Abdominal - surgery ; Biological and medical sciences ; Female ; Humans ; Luminescent Measurements ; Male ; Medical sciences ; Middle Aged ; Reperfusion Injury - metabolism ; Surgery (general aspects). 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Further specimens were taken from the central line at 2, 6 and 24 h after operation. Antioxidant concentration in the peripheral, central and inferior mesenteric blood were similar, indicating that anaesthesia and surgical dissection had no effect. Levels decreased significantly in central and inferior mesenteric blood during and after clamping, but returned to normal by 24 h. These results confirm ischaemia‐reperfusion phenomena in AAA repair.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants - metabolism</subject><subject>Aortic Aneurysm, Abdominal - metabolism</subject><subject>Aortic Aneurysm, Abdominal - surgery</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reperfusion Injury - metabolism</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUM9PwjAYbYwGEb16M9nBeBt-7dd246ioqCEaIsZj03WdKY6B7Rbhv3cEAqcvL-9H3vcIuaTQpwDsNpuFPk0BUgREcUS6FKWIGZXpMekCQBJTZHhKzkKYAVAEwTqkk0opGCRdgndV7RYrl-uqjnK7LG0LqyhvvKu-I73wtTORrmzj12EeebvUzp-Tk0KXwV7sbo98Pj1Oh8_x-H30Mrwbx4YnXMRYcAmcCUNFVmDGOGVFWxSoMdQkwqS5ZKLIBlpysJnQRYFGcptTRpOMMY49crPNXfrFb2NDreYuGFuWbZ9FE1SSQtqmYiu82gmbbG5ztfRurv1a7b5s-esdr4PRZeF1ZVzYyxCAU9jEDLayP1fa9Z6moDZLq3ZpdVha3b9-HFDrjbdeF2q72nu1_1EywUSor7eRepjgdCwpUxP8B6Omfzc</recordid><startdate>199603</startdate><enddate>199603</enddate><creator>Khaira, H. S.</creator><creator>Maxwell, S. R. J.</creator><creator>Thomason, H.</creator><creator>Thorpe, G. H. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant depletion during aortic aneurysm repair</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1996-03</date><risdate>1996</risdate><volume>83</volume><issue>3</issue><spage>401</spage><epage>403</epage><pages>401-403</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Ischaemia–reperfusion injury generates oxygen‐derived free radicals leading to local and distant damage. A simple method of following oxidative activity is to measure the consumption of endogenous scavenging antioxidants; an enhanced chemiluminescent assay was used to study this phenomenon in 21 patients undergoing surgery for abdominal aortic aneurysm (AAA). Samples of peripheral venous blood were taken before induction of anaesthesia and then from a central venous line and the inferior mesenteric vein before, during, and after clamping of the aorta. 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| fulltext | fulltext |
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| ispartof | British journal of surgery, 1996-03, Vol.83 (3), p.401-403 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Aged, 80 and over Antioxidants - metabolism Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - surgery Biological and medical sciences Female Humans Luminescent Measurements Male Medical sciences Middle Aged Reperfusion Injury - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Antioxidant depletion during aortic aneurysm repair |
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