Meta-analysis of the placebo-treated groups in clinical trials of progressive MS

The behavior of the control groups can substantially affect the power and outcome of a clinical trial.We report a meta-analysis of the control groups of four large, double-blind, placebo-controlled clinical trials of immunosuppressive treatment of progressive MS to address the sensitivity of five hy...

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Veröffentlicht in:	Neurology 1996-06, Vol.46 (6), p.1613-1619
Hauptverfasser:	Weinshenker, Brian G, Issa, Maher, Baskerville, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases - drug therapy Autoimmune Diseases - epidemiology Autoimmune Diseases - therapy Azathioprine - therapeutic use Biological and medical sciences Brain Stem - physiopathology Clinical Trials, Phase III as Topic Cyclosporine - therapeutic use Disease Progression Double-Blind Method Female Humans Immunosuppressive Agents - therapeutic use Male Medical sciences Methylprednisolone - therapeutic use Multiple Sclerosis - drug therapy Multiple Sclerosis - epidemiology Multiple Sclerosis - therapy Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Placebos Plasma Exchange Pyramidal Tracts - physiopathology Randomized Controlled Trials as Topic Severity of Illness Index Treatment Failure
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