Inhibitory mechanisms of H+‐ATPase inhibitor bafilomycin A1 and carbonic anhydrase II inhibitor acetazolamide on experimental bone resorption

The effects of the vacuolar‐type H+‐ATPase inhibitor bafilomycin A1 (baf. A1) and the carbonic anhydrase II inhibitor acetazolamide (AZ) on bone resorption and procathepsin L secretion of rat osteoclasts were investigated using the bone slice assay method, pit formation test. Baf. A1 completely supp...

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Veröffentlicht in:	FEBS letters 1996-06, Vol.387 (2-3), p.175-178
Hauptverfasser:	Ohba, Y, Ohba, T, Sumitani, K, Tagami-Kondoh, K, Hiura, K, Miki, Y, Kakegawa, H, Takano-Yamamoto, T, Katunuma, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide Acetazolamide - pharmacology Adenosine Triphosphatases - antagonists & inhibitors Animals Anti-Bacterial Agents - pharmacology Bafilomycin A1 Bone resorption Bone Resorption - metabolism Carbonic Anhydrase Inhibitors - pharmacology Cathepsin L Cathepsins - metabolism Enzyme Precursors - metabolism Humans In Vitro Techniques Macrolides Osteoclasts - drug effects Osteoclasts - metabolism Parathyroid Hormone - pharmacology Procathepsin L Proton Pumps - drug effects Rats Rats, Sprague-Dawley Vacuolar Proton-Translocating ATPases
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