Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis
OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of end...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1996-05, Vol.174 (5), p.1522-1526 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Punnonen, Juha Teisala, Klaus Ranta, Hannu Bennett, Bruce Punnonen, Reijo |
| description | OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometriosis.
STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay.
RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 ± 407 pg/ml and 133 ± 38 pg/ml, respectively (
p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 ± 38 vs 128 ± 21,
p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups.
CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis. (AM J OBSTET GYNECOL 1996;174:1522-6.) |
| doi_str_mv | 10.1016/S0002-9378(96)70600-2 |
| format | Article |
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STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay.
RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 ± 407 pg/ml and 133 ± 38 pg/ml, respectively (
p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 ± 38 vs 128 ± 21,
p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups.
CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis. (AM J OBSTET GYNECOL 1996;174:1522-6.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(96)70600-2</identifier><identifier>PMID: 9065123</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adult ; Ascitic Fluid - metabolism ; Biological and medical sciences ; cytokine ; Endometriosis ; Endometriosis - metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Female genital diseases ; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; interleukin-10 ; Interleukin-10 - metabolism ; interleukin-6 ; Interleukin-6 - metabolism ; Medical sciences ; Non tumoral diseases</subject><ispartof>American journal of obstetrics and gynecology, 1996-05, Vol.174 (5), p.1522-1526</ispartof><rights>1996 Mosby, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-fbe0a1f15a90a83178119fc6aefe8fbc793cf99ecc7d0950513227b57b1a23b93</citedby><cites>FETCH-LOGICAL-c418t-fbe0a1f15a90a83178119fc6aefe8fbc793cf99ecc7d0950513227b57b1a23b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937896706002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3114843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9065123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Punnonen, Juha</creatorcontrib><creatorcontrib>Teisala, Klaus</creatorcontrib><creatorcontrib>Ranta, Hannu</creatorcontrib><creatorcontrib>Bennett, Bruce</creatorcontrib><creatorcontrib>Punnonen, Reijo</creatorcontrib><creatorcontrib>DNAX Research Institute is supported by Schering-Plough Corporation. This study was also supported by the Academy of Finland and the Finnish Cancer Society</creatorcontrib><title>Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometriosis.
STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay.
RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 ± 407 pg/ml and 133 ± 38 pg/ml, respectively (
p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 ± 38 vs 128 ± 21,
p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups.
CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis. (AM J OBSTET GYNECOL 1996;174:1522-6.)</description><subject>Adult</subject><subject>Ascitic Fluid - metabolism</subject><subject>Biological and medical sciences</subject><subject>cytokine</subject><subject>Endometriosis</subject><subject>Endometriosis - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>interleukin-10</subject><subject>Interleukin-10 - metabolism</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo6-zqT1jIQUQPrZVkOh8nkUXXhQUP6jmk0xU2biY9JukV_73dO8OAJ0-hUs9bVTyEXDJ4x4DJ998AgHdGKP3GyLcKJEDHn5ANA6M6qaV-SjYn5Dk5r_XnWnLDz8iZAdkzLjbk_ib7gq7iSBM-YKp0CjTmhiXhfB9zJ6nL4z8_DJaStjukeyyxTRldoiHNcVyze9ci5lbp79juKOZx2mErcaqxviDPgksVXx7fC_Lj86fvV1-626_XN1cfbzu_Zbp1YUBwLLDeGXBaMKUZM8FLhwF1GLwywgdj0Hs1gumhZ4JzNfRqYI6LwYgL8vowd1-mXzPWZnexekzJZZzmapUGtRVGLmB_AH2Zai0Y7L7EnSt_LAO7SraPku1q0BppHyVbvuQujwvmYYfjKXW0uvRfHfuuepdCcdnHesIEY1u9XbEPB2zRjg8Ri61-cedxjAV9s-MU_3PIX6U6meY</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Punnonen, Juha</creator><creator>Teisala, Klaus</creator><creator>Ranta, Hannu</creator><creator>Bennett, Bruce</creator><creator>Punnonen, Reijo</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis</title><author>Punnonen, Juha ; Teisala, Klaus ; Ranta, Hannu ; Bennett, Bruce ; Punnonen, Reijo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-fbe0a1f15a90a83178119fc6aefe8fbc793cf99ecc7d0950513227b57b1a23b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Ascitic Fluid - metabolism</topic><topic>Biological and medical sciences</topic><topic>cytokine</topic><topic>Endometriosis</topic><topic>Endometriosis - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>interleukin-10</topic><topic>Interleukin-10 - metabolism</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Punnonen, Juha</creatorcontrib><creatorcontrib>Teisala, Klaus</creatorcontrib><creatorcontrib>Ranta, Hannu</creatorcontrib><creatorcontrib>Bennett, Bruce</creatorcontrib><creatorcontrib>Punnonen, Reijo</creatorcontrib><creatorcontrib>DNAX Research Institute is supported by Schering-Plough Corporation. This study was also supported by the Academy of Finland and the Finnish Cancer Society</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Punnonen, Juha</au><au>Teisala, Klaus</au><au>Ranta, Hannu</au><au>Bennett, Bruce</au><au>Punnonen, Reijo</au><aucorp>DNAX Research Institute is supported by Schering-Plough Corporation. This study was also supported by the Academy of Finland and the Finnish Cancer Society</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>174</volume><issue>5</issue><spage>1522</spage><epage>1526</epage><pages>1522-1526</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometriosis.
STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay.
RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 ± 407 pg/ml and 133 ± 38 pg/ml, respectively (
p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 ± 38 vs 128 ± 21,
p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups.
CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis. (AM J OBSTET GYNECOL 1996;174:1522-6.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>9065123</pmid><doi>10.1016/S0002-9378(96)70600-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1996-05, Vol.174 (5), p.1522-1526 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Ascitic Fluid - metabolism Biological and medical sciences cytokine Endometriosis Endometriosis - metabolism Enzyme-Linked Immunosorbent Assay Female Female genital diseases Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Gynecology. Andrology. Obstetrics Humans interleukin-10 Interleukin-10 - metabolism interleukin-6 Interleukin-6 - metabolism Medical sciences Non tumoral diseases |
| title | Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis |
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