Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism
The aim of this study was to determine whether a ketogenic diet could decrease nitrogen losses in cachectic cancer patients and at the same time reduce the supply of glucose for tumor energy metabolism. Five patients with malignant disease and severe weight loss (mean 32%) were fed via a fine bore n...
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| Veröffentlicht in: | The American journal of clinical nutrition 1988-01, Vol.47 (1), p.42-48 |
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| container_title | The American journal of clinical nutrition |
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| creator | Fearon, KC Borland, W Preston, T Tisdale, MJ Shenkin, A Calman, KC |
| description | The aim of this study was to determine whether a ketogenic diet could decrease nitrogen losses in cachectic cancer patients and at the same time reduce the supply of glucose for tumor energy metabolism. Five patients with malignant disease and severe weight loss (mean 32%) were fed via a fine bore nasogastric tube. A normal diet was given for 6 d and this was followed by 7 d of an isonitrogenous, isocaloric, ketogenic diet. Both diets were well tolerated. At 7 d the mean ketone body concentration in the blood of patients fed the ketogenic diet was 1.21 +/- 0.33 mM. This ketosis was associated with a significant reduction of the concentration in blood of glucose, lactate, and pyruvate (p less than 0.05). There was, however, no significant alteration in host N balance or whole-body protein synthesis, degradation, or turnover rates. Whether the change from glucose- to fat-derived energy substrates might reduce tumor growth rates in the long term remains to be determined. |
| doi_str_mv | 10.1093/ajcn/47.1.42 |
| format | Article |
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Five patients with malignant disease and severe weight loss (mean 32%) were fed via a fine bore nasogastric tube. A normal diet was given for 6 d and this was followed by 7 d of an isonitrogenous, isocaloric, ketogenic diet. Both diets were well tolerated. At 7 d the mean ketone body concentration in the blood of patients fed the ketogenic diet was 1.21 +/- 0.33 mM. This ketosis was associated with a significant reduction of the concentration in blood of glucose, lactate, and pyruvate (p less than 0.05). There was, however, no significant alteration in host N balance or whole-body protein synthesis, degradation, or turnover rates. 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Whether the change from glucose- to fat-derived energy substrates might reduce tumor growth rates in the long term remains to be determined.</description><subject>Acidosis - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>Cachexia - metabolism</subject><subject>Cachexia - therapy</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Energy Intake</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>General aspects</subject><subject>Gluconeogenesis</subject><subject>Humans</subject><subject>Ketone Bodies - blood</subject><subject>Ketosis - etiology</subject><subject>Ketosis - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>Nitrogen - metabolism</subject><subject>Proteins - metabolism</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtr3DAUhUVJSCdpd90WtAhZxRO9bMndlSEvCGSTbroRsnzVKrWtVFcemn9fDzNkldWFcz7OhY-QL5ytOWvllXv205XSa75W4gNZ8VaaSgqmj8iKMSaqljf1R3KK-MwYF8o0J-REciHqWqzIz42bPGTqnf8N_6L7RuMUhhmWkKZA8RULjNHTP1ASRqRpojh3WLIrQAfYwoDUTT2dYsnpF0x0hOK6NEQcP5Hj4AaEz4d7Rn7cXD9t7qqHx9v7zfeHyivGSgWSOdWaxpiu4Y1o604G1UvVG931RoI2IXjpeR2U6JtOGM6hM0sRgjJKM3lGLva7Lzn9nQGLHSN6GAY3QZrRasO0kkYu4OUe9DkhZgj2JcfR5VfLmd2ptDuVVmnLrRIL_vWwO3cj9G_wwd3Snx96h94NIS8mI75humZaSL1gzR5bVME2Qrbo485vHzP4YvsU3___H0Pwj6E</recordid><startdate>198801</startdate><enddate>198801</enddate><creator>Fearon, KC</creator><creator>Borland, W</creator><creator>Preston, T</creator><creator>Tisdale, MJ</creator><creator>Shenkin, A</creator><creator>Calman, KC</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198801</creationdate><title>Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism</title><author>Fearon, KC ; Borland, W ; Preston, T ; Tisdale, MJ ; Shenkin, A ; Calman, KC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-e30a498688b616295b3f4d34d87bd83e78ffc3c15f42d6b2811eb883eff484703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acidosis - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>Cachexia - metabolism</topic><topic>Cachexia - therapy</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Energy Intake</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>General aspects</topic><topic>Gluconeogenesis</topic><topic>Humans</topic><topic>Ketone Bodies - blood</topic><topic>Ketosis - etiology</topic><topic>Ketosis - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>Nitrogen - metabolism</topic><topic>Proteins - metabolism</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fearon, KC</creatorcontrib><creatorcontrib>Borland, W</creatorcontrib><creatorcontrib>Preston, T</creatorcontrib><creatorcontrib>Tisdale, MJ</creatorcontrib><creatorcontrib>Shenkin, A</creatorcontrib><creatorcontrib>Calman, KC</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fearon, KC</au><au>Borland, W</au><au>Preston, T</au><au>Tisdale, MJ</au><au>Shenkin, A</au><au>Calman, KC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1988-01</date><risdate>1988</risdate><volume>47</volume><issue>1</issue><spage>42</spage><epage>48</epage><pages>42-48</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The aim of this study was to determine whether a ketogenic diet could decrease nitrogen losses in cachectic cancer patients and at the same time reduce the supply of glucose for tumor energy metabolism. 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| ispartof | The American journal of clinical nutrition, 1988-01, Vol.47 (1), p.42-48 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acidosis - metabolism Biological and medical sciences Blood Glucose - metabolism Body Weight Cachexia - metabolism Cachexia - therapy Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Energy Intake Enteral Nutrition Female General aspects Gluconeogenesis Humans Ketone Bodies - blood Ketosis - etiology Ketosis - metabolism Liver - metabolism Male Medical sciences Neoplasms - metabolism Neoplasms - therapy Nitrogen - metabolism Proteins - metabolism Time Factors Tumors |
| title | Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism |
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