Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in subjects with coronary artery disease
Sodium-lithium countertransport activity, external affinity for sodium (k Na) and maximal rate of turnover (V max), were characterized in 21 male subjects (aged 45 to 65 years) with angiographically proven coronary artery disease; these were compared with a matched group of healthy controls. No sign...
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| Veröffentlicht in: | American journal of hypertension 1996-02, Vol.9 (2), p.184-187 |
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| container_title | American journal of hypertension |
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| creator | Hardman, Timothy C. Barlow, Richard Dubrey, Simon W. Croft, Paula Lant, Ariel F. |
| description | Sodium-lithium countertransport activity, external affinity for sodium (k
Na) and maximal rate of turnover (V
max), were characterized in 21 male subjects (aged 45 to 65 years) with angiographically proven coronary artery disease; these were compared with a matched group of healthy controls.
No significant differences in countertransport activity were noted between the coronary artery disease patients and the healthy controls. By contrast, the median [range] k
Na in the coronary artery disease group (8.5 [2.6 to 30.5] mmol/L Na) was significantly lower than that in the controls (59.9 [5.9 to 240.5] mmol/L Na;
P < .0001). This reduction was accompanied by a significantly lower mean V
max (controls 0.403 ± 0.187 ν coronary artery disease group 0.248 ± 0.121 mmol Li/L RBC/h;
P < .01).
The findings suggest that disturbed behavior of the sodium-lithium countertransporter is not confined to hypertension but may represent a broader-based membrane dysfunction associated with vascular disease. |
| doi_str_mv | 10.1016/0895-7061(95)00347-9 |
| format | Article |
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Na) and maximal rate of turnover (V
max), were characterized in 21 male subjects (aged 45 to 65 years) with angiographically proven coronary artery disease; these were compared with a matched group of healthy controls.
No significant differences in countertransport activity were noted between the coronary artery disease patients and the healthy controls. By contrast, the median [range] k
Na in the coronary artery disease group (8.5 [2.6 to 30.5] mmol/L Na) was significantly lower than that in the controls (59.9 [5.9 to 240.5] mmol/L Na;
P < .0001). This reduction was accompanied by a significantly lower mean V
max (controls 0.403 ± 0.187 ν coronary artery disease group 0.248 ± 0.121 mmol Li/L RBC/h;
P < .01).
The findings suggest that disturbed behavior of the sodium-lithium countertransporter is not confined to hypertension but may represent a broader-based membrane dysfunction associated with vascular disease.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/0895-7061(95)00347-9</identifier><identifier>PMID: 8924269</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Antiporters - blood ; Biological and medical sciences ; Cardiology. Vascular system ; coronary artery disease ; Coronary Disease - blood ; Coronary heart disease ; erythrocytes ; Erythrocytes - metabolism ; Heart ; Humans ; Kinetics ; Male ; Medical sciences ; Middle Aged ; Reference Values ; Sodium-lithuim countertransport</subject><ispartof>American journal of hypertension, 1996-02, Vol.9 (2), p.184-187</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-263e3c97ceb639bee169a9b1767b71d13fffe0743f0835168f49406af9f8eb093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3027007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8924269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardman, Timothy C.</creatorcontrib><creatorcontrib>Barlow, Richard</creatorcontrib><creatorcontrib>Dubrey, Simon W.</creatorcontrib><creatorcontrib>Croft, Paula</creatorcontrib><creatorcontrib>Lant, Ariel F.</creatorcontrib><title>Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in subjects with coronary artery disease</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Sodium-lithium countertransport activity, external affinity for sodium (k
Na) and maximal rate of turnover (V
max), were characterized in 21 male subjects (aged 45 to 65 years) with angiographically proven coronary artery disease; these were compared with a matched group of healthy controls.
No significant differences in countertransport activity were noted between the coronary artery disease patients and the healthy controls. By contrast, the median [range] k
Na in the coronary artery disease group (8.5 [2.6 to 30.5] mmol/L Na) was significantly lower than that in the controls (59.9 [5.9 to 240.5] mmol/L Na;
P < .0001). This reduction was accompanied by a significantly lower mean V
max (controls 0.403 ± 0.187 ν coronary artery disease group 0.248 ± 0.121 mmol Li/L RBC/h;
P < .01).
The findings suggest that disturbed behavior of the sodium-lithium countertransporter is not confined to hypertension but may represent a broader-based membrane dysfunction associated with vascular disease.</description><subject>Aged</subject><subject>Antiporters - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>coronary artery disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary heart disease</subject><subject>erythrocytes</subject><subject>Erythrocytes - metabolism</subject><subject>Heart</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Sodium-lithuim countertransport</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EKtvCG4DwAVX0ELDjxI4vldpCW6AIIYGEuFiOM1a8ZOPFdoB9exyyWm6cxtb_zcj-BqEnlLykhPJXpJF1IQinL2R9RgirRCHvoRVthCyoJPV9tDogD9FxjGtCSMU5PUJHjSyrkssVmt67EZIz2PQ6aJMguJivEXuLUw8Ywi71wZtdAhx956ZNMbjU54qNn8bMp6DHuPUhH7EbcZzaNZgU8a-MZSb4UYcd1nO-w52LoCM8Qg-sHiI83tcT9OX6zeer2-Lu483bq4u7wlSySkXJGTAjhYGWM9kCUC61bKngohW0o8xaC0RUzJKG1ZQ3NrcRrq20DbREshN0uszdBv9jgpjUxkUDw6BH8FNUoiEia-AZrBbQBB9jAKu2wW3ywxUlaratZpVqVqly_WtbzfOf7udP7Qa6Q9Neb86f73MdjR5sVmVcPGCMlIIQkbFnCzbqNAU45HrdUyk5nQcVC5G3A7__AeG74oKJWt1-_aYua_qufH3zSX3I_PnCQ7b700FQ0TgYDXQu5O2ozrv__-wPKoa4VA</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Hardman, Timothy C.</creator><creator>Barlow, Richard</creator><creator>Dubrey, Simon W.</creator><creator>Croft, Paula</creator><creator>Lant, Ariel F.</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in subjects with coronary artery disease</title><author>Hardman, Timothy C. ; Barlow, Richard ; Dubrey, Simon W. ; Croft, Paula ; Lant, Ariel F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-263e3c97ceb639bee169a9b1767b71d13fffe0743f0835168f49406af9f8eb093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Antiporters - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>coronary artery disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary heart disease</topic><topic>erythrocytes</topic><topic>Erythrocytes - metabolism</topic><topic>Heart</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Sodium-lithuim countertransport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardman, Timothy C.</creatorcontrib><creatorcontrib>Barlow, Richard</creatorcontrib><creatorcontrib>Dubrey, Simon W.</creatorcontrib><creatorcontrib>Croft, Paula</creatorcontrib><creatorcontrib>Lant, Ariel F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardman, Timothy C.</au><au>Barlow, Richard</au><au>Dubrey, Simon W.</au><au>Croft, Paula</au><au>Lant, Ariel F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in subjects with coronary artery disease</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>9</volume><issue>2</issue><spage>184</spage><epage>187</epage><pages>184-187</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><abstract>Sodium-lithium countertransport activity, external affinity for sodium (k
Na) and maximal rate of turnover (V
max), were characterized in 21 male subjects (aged 45 to 65 years) with angiographically proven coronary artery disease; these were compared with a matched group of healthy controls.
No significant differences in countertransport activity were noted between the coronary artery disease patients and the healthy controls. By contrast, the median [range] k
Na in the coronary artery disease group (8.5 [2.6 to 30.5] mmol/L Na) was significantly lower than that in the controls (59.9 [5.9 to 240.5] mmol/L Na;
P < .0001). This reduction was accompanied by a significantly lower mean V
max (controls 0.403 ± 0.187 ν coronary artery disease group 0.248 ± 0.121 mmol Li/L RBC/h;
P < .01).
The findings suggest that disturbed behavior of the sodium-lithium countertransporter is not confined to hypertension but may represent a broader-based membrane dysfunction associated with vascular disease.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8924269</pmid><doi>10.1016/0895-7061(95)00347-9</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 1996-02, Vol.9 (2), p.184-187 |
| issn | 0895-7061 1879-1905 1941-7225 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Antiporters - blood Biological and medical sciences Cardiology. Vascular system coronary artery disease Coronary Disease - blood Coronary heart disease erythrocytes Erythrocytes - metabolism Heart Humans Kinetics Male Medical sciences Middle Aged Reference Values Sodium-lithuim countertransport |
| title | Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in subjects with coronary artery disease |
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