Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

Mice lacking p27(Kip1) have been created by gene targeting in embryonic stem cells. These mice are larger than the control animals, with thymus, pituitary, and adrenal glands and gonadal organs exhibiting striking enlargement. CDK2 activity is elevated about 10-fold in p27(-/-) thymocytes. Developme...

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Veröffentlicht in:	Cell 1996-05, Vol.85 (5), p.707-720
Hauptverfasser:	Nakayama, K, Ishida, N, Shirane, M, Inomata, A, Inoue, T, Shishido, N, Horii, I, Loh, D Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Body Constitution - genetics Cell Cycle - genetics Cell Cycle Proteins Cell Division - drug effects Cell Division - genetics Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - antagonists & inhibitors DNA Primers - genetics DNA, Complementary - genetics Enzyme Inhibitors - metabolism Female Gene Expression Gene Targeting Genes, Tumor Suppressor Heterozygote Hyperplasia Infertility, Female - genetics Male Mice Mice, Knockout Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Molecular Sequence Data Phenotype Pituitary Neoplasms - genetics Polyenes - pharmacology Retinal Dysplasia - genetics Sirolimus Tissue Distribution Transforming Growth Factor alpha - pharmacology Tumor Suppressor Proteins
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