Detailed Behavioral Analysis of Water Maze Acquisition Under Systemic NMDA or Muscarinic Antagonism: Nonspatial Pretraining Eliminates Spatial Learning Deficits
A detailed behavioral analysis of water-maze acquisition showed that the N -methyl- d -aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in...
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| Veröffentlicht in: | Behavioral neuroscience 1996-02, Vol.110 (1), p.103-116 |
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| container_title | Behavioral neuroscience |
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| creator | Saucier, Deborah Hargreaves, Eric L Boon, Francis Vanderwolf, C. H Cain, Donald Peter |
| description | A detailed behavioral analysis of water-maze acquisition showed that the
N
-methyl-
d
-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze. |
| doi_str_mv | 10.1037/0735-7044.110.1.103 |
| format | Article |
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N
-methyl-
d
-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.110.1.103</identifier><identifier>PMID: 8652059</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Amino Acids - pharmacology ; Animal ; Animal behavior ; Animals ; Attention - drug effects ; Behavioral psychophysiology ; Biochemistry ; Biological and medical sciences ; Brain - drug effects ; Excitatory Amino Acid Antagonists - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Learning ; Maze Learning ; Maze Learning - drug effects ; Mental Recall - drug effects ; Motor Activity - drug effects ; Motor Skills - drug effects ; Muscarinic Antagonists - pharmacology ; N-Methyl-D-Aspartate ; Neurotransmission and behavior ; Orientation - drug effects ; Perceptual Motor Processes ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Reaction Time - drug effects ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Retention (Psychology) - drug effects ; Rodents ; Scopolamine ; Scopolamine Hydrobromide - pharmacology</subject><ispartof>Behavioral neuroscience, 1996-02, Vol.110 (1), p.103-116</ispartof><rights>1996 American Psychological Association</rights><rights>1996 INIST-CNRS</rights><rights>Copyright American Psychological Association Feb 1996</rights><rights>1996, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a481t-f746dabdf036f0ebea7b42a783067380b73041bfc38deb52515a7e5aadd560543</citedby><orcidid>0000-0001-5311-9804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2995515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8652059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gallagher, Michela</contributor><creatorcontrib>Saucier, Deborah</creatorcontrib><creatorcontrib>Hargreaves, Eric L</creatorcontrib><creatorcontrib>Boon, Francis</creatorcontrib><creatorcontrib>Vanderwolf, C. H</creatorcontrib><creatorcontrib>Cain, Donald Peter</creatorcontrib><title>Detailed Behavioral Analysis of Water Maze Acquisition Under Systemic NMDA or Muscarinic Antagonism: Nonspatial Pretraining Eliminates Spatial Learning Deficits</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>A detailed behavioral analysis of water-maze acquisition showed that the
N
-methyl-
d
-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze.</description><subject>Amino Acids - pharmacology</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Attention - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Learning</subject><subject>Maze Learning</subject><subject>Maze Learning - drug effects</subject><subject>Mental Recall - drug effects</subject><subject>Motor Activity - drug effects</subject><subject>Motor Skills - drug effects</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>N-Methyl-D-Aspartate</subject><subject>Neurotransmission and behavior</subject><subject>Orientation - drug effects</subject><subject>Perceptual Motor Processes</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Reaction Time - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Retention (Psychology) - drug effects</subject><subject>Rodents</subject><subject>Scopolamine</subject><subject>Scopolamine Hydrobromide - pharmacology</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKsvCL0BIESqcmjKOv5JjaKEgtXCAiqM1cRxwlThbO0Fafn0d7WolKlROlp55ZqyZl5CXFE4pMPUOFBO5As5P6YIW-IisaMWqHKDkj8nqYDwlz2K8AQAOXByRo1KKAkS1IubcTuh622bv7S_87caAfVZ77LfRxWzssh842ZBd4R-b1eZ2dtFNbvTZtW8T_raNkx2cyb5cndfZmLw5GgzOJ1T7CX-O3sXhOXnSYR_ti_27JtcfP3w_-5Rffr34fFZf5shLOuWd4rLFpu2AyQ5sY1E1vEBVMpCKldAoBpw2nWFlaxtRCCpQWYHYtkKC4GxN3u7mbsJ4O9s46cFFY_sevR3nqFUJUhaV-K9IhZSy4ov4-p54M84hXSdqSTkrBK-Kh6QCWAW0TCusCdtJJowxBtvpTXADhq2moJc09ZKVXrLSdEELTF2v9qPnZrDtoWcfX6of7-uY7t53Ab1x8aAVVSXSlZJ2stNwg3oTtymiyZneRjOHYP2kG2__-vXNv_V73h3NtcGl</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Saucier, Deborah</creator><creator>Hargreaves, Eric L</creator><creator>Boon, Francis</creator><creator>Vanderwolf, C. H</creator><creator>Cain, Donald Peter</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5311-9804</orcidid></search><sort><creationdate>19960201</creationdate><title>Detailed Behavioral Analysis of Water Maze Acquisition Under Systemic NMDA or Muscarinic Antagonism</title><author>Saucier, Deborah ; Hargreaves, Eric L ; Boon, Francis ; Vanderwolf, C. H ; Cain, Donald Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a481t-f746dabdf036f0ebea7b42a783067380b73041bfc38deb52515a7e5aadd560543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acids - pharmacology</topic><topic>Animal</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Attention - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Learning</topic><topic>Maze Learning</topic><topic>Maze Learning - drug effects</topic><topic>Mental Recall - drug effects</topic><topic>Motor Activity - drug effects</topic><topic>Motor Skills - drug effects</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>N-Methyl-D-Aspartate</topic><topic>Neurotransmission and behavior</topic><topic>Orientation - drug effects</topic><topic>Perceptual Motor Processes</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Reaction Time - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Retention (Psychology) - drug effects</topic><topic>Rodents</topic><topic>Scopolamine</topic><topic>Scopolamine Hydrobromide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saucier, Deborah</creatorcontrib><creatorcontrib>Hargreaves, Eric L</creatorcontrib><creatorcontrib>Boon, Francis</creatorcontrib><creatorcontrib>Vanderwolf, C. 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H</au><au>Cain, Donald Peter</au><au>Gallagher, Michela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detailed Behavioral Analysis of Water Maze Acquisition Under Systemic NMDA or Muscarinic Antagonism: Nonspatial Pretraining Eliminates Spatial Learning Deficits</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>110</volume><issue>1</issue><spage>103</spage><epage>116</epage><pages>103-116</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>A detailed behavioral analysis of water-maze acquisition showed that the
N
-methyl-
d
-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>8652059</pmid><doi>10.1037/0735-7044.110.1.103</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5311-9804</orcidid></addata></record> |
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| ispartof | Behavioral neuroscience, 1996-02, Vol.110 (1), p.103-116 |
| issn | 0735-7044 1939-0084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78066295 |
| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Amino Acids - pharmacology Animal Animal behavior Animals Attention - drug effects Behavioral psychophysiology Biochemistry Biological and medical sciences Brain - drug effects Excitatory Amino Acid Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology Learning Maze Learning Maze Learning - drug effects Mental Recall - drug effects Motor Activity - drug effects Motor Skills - drug effects Muscarinic Antagonists - pharmacology N-Methyl-D-Aspartate Neurotransmission and behavior Orientation - drug effects Perceptual Motor Processes Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Reaction Time - drug effects Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Retention (Psychology) - drug effects Rodents Scopolamine Scopolamine Hydrobromide - pharmacology |
| title | Detailed Behavioral Analysis of Water Maze Acquisition Under Systemic NMDA or Muscarinic Antagonism: Nonspatial Pretraining Eliminates Spatial Learning Deficits |
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