Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis
The growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10−5M) fluconazole relative to growth in drug free medium. Using a receiver operator characteristic curve, a relative growth in fluconazole o...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1996-02, Vol.37 (2), p.275-283 |
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| container_end_page | 283 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Cartledge, Jonathan D. Midgley, Jenifer Gazzard, Brain G. |
| description | The growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10−5M) fluconazole relative to growth in drug free medium. Using a receiver operator characteristic curve, a relative growth in fluconazole of ≥88% best discriminated between isolates from 56 patients who responded to treatment with fluconazole and 48 who failed to respond to 7 days, treatment with at least 100 mg/d drug with a sensitivity of 98% and a specificity of 96%. When the isolates from the eight patients with mixed infections due to both resistant and susceptible yeasts were excluded, the sensitivity and specificity both reached 100%. Relative growth of Candida spp. in a single concentration of fluconazole can therefore be used to accurately predict the clinical response to standard fluconazole treatment of thrush in patients infected with HIV. |
| doi_str_mv | 10.1093/jac/37.2.275 |
| format | Article |
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Using a receiver operator characteristic curve, a relative growth in fluconazole of ≥88% best discriminated between isolates from 56 patients who responded to treatment with fluconazole and 48 who failed to respond to 7 days, treatment with at least 100 mg/d drug with a sensitivity of 98% and a specificity of 96%. When the isolates from the eight patients with mixed infections due to both resistant and susceptible yeasts were excluded, the sensitivity and specificity both reached 100%. Relative growth of Candida spp. in a single concentration of fluconazole can therefore be used to accurately predict the clinical response to standard fluconazole treatment of thrush in patients infected with HIV.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/37.2.275</identifier><identifier>PMID: 8707737</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>AIDS-Related Opportunistic Infections - drug therapy ; AIDS/HIV ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Candida ; Candida - drug effects ; Candida - growth & development ; Candidiasis, Oral - drug therapy ; Drug Resistance, Microbial ; Esophageal Diseases - drug therapy ; Evaluation Studies as Topic ; Fluconazole - pharmacology ; Fluconazole - therapeutic use ; HIV Seropositivity ; human immunodeficiency virus ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Prospective Studies ; Reproducibility of Results ; ROC Curve</subject><ispartof>Journal of antimicrobial chemotherapy, 1996-02, Vol.37 (2), p.275-283</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-98dc1af259aaaf074c063d44f74d27f525e301918c779b151ab6f2f8fb03aa033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3052829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8707737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cartledge, Jonathan D.</creatorcontrib><creatorcontrib>Midgley, Jenifer</creatorcontrib><creatorcontrib>Gazzard, Brain G.</creatorcontrib><title>Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10−5M) fluconazole relative to growth in drug free medium. Using a receiver operator characteristic curve, a relative growth in fluconazole of ≥88% best discriminated between isolates from 56 patients who responded to treatment with fluconazole and 48 who failed to respond to 7 days, treatment with at least 100 mg/d drug with a sensitivity of 98% and a specificity of 96%. When the isolates from the eight patients with mixed infections due to both resistant and susceptible yeasts were excluded, the sensitivity and specificity both reached 100%. Relative growth of Candida spp. in a single concentration of fluconazole can therefore be used to accurately predict the clinical response to standard fluconazole treatment of thrush in patients infected with HIV.</description><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS/HIV</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>Candida - growth & development</subject><subject>Candidiasis, Oral - drug therapy</subject><subject>Drug Resistance, Microbial</subject><subject>Esophageal Diseases - drug therapy</subject><subject>Evaluation Studies as Topic</subject><subject>Fluconazole - pharmacology</subject><subject>Fluconazole - therapeutic use</subject><subject>HIV Seropositivity</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candida - drug effects</topic><topic>Candida - growth & development</topic><topic>Candidiasis, Oral - drug therapy</topic><topic>Drug Resistance, Microbial</topic><topic>Esophageal Diseases - drug therapy</topic><topic>Evaluation Studies as Topic</topic><topic>Fluconazole - pharmacology</topic><topic>Fluconazole - therapeutic use</topic><topic>HIV Seropositivity</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cartledge, Jonathan D.</creatorcontrib><creatorcontrib>Midgley, Jenifer</creatorcontrib><creatorcontrib>Gazzard, Brain G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartledge, Jonathan D.</au><au>Midgley, Jenifer</au><au>Gazzard, Brain G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>37</volume><issue>2</issue><spage>275</spage><epage>283</epage><pages>275-283</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>The growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10−5M) fluconazole relative to growth in drug free medium. 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| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1996-02, Vol.37 (2), p.275-283 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford Journals - Connect here FIRST to enable access; Free E-Journal (出版社公開部分のみ）; Free Full-Text Journals in Chemistry |
| subjects | AIDS-Related Opportunistic Infections - drug therapy AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Biological and medical sciences Candida Candida - drug effects Candida - growth & development Candidiasis, Oral - drug therapy Drug Resistance, Microbial Esophageal Diseases - drug therapy Evaluation Studies as Topic Fluconazole - pharmacology Fluconazole - therapeutic use HIV Seropositivity human immunodeficiency virus Humans Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Prospective Studies Reproducibility of Results ROC Curve |
| title | Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis |
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