Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels

It has been proposed that mucoadhesives which adhere to the gastric mucus layer may be used to prolong gastric retention time of oral dosage forms. Preliminary studies, using acrylic hydrogels, have established that the density of carboxyl groups on the polymer chain is important for mucoadhesion. T...

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Veröffentlicht in:	Pharmaceutical research 1987-12, Vol.4 (6), p.457-464
Hauptverfasser:	PARK, H, ROBINSON, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - metabolism Adhesiveness Animals Biological and medical sciences Gastric Mucosa - metabolism General pharmacology Hydrogel, Polyethylene Glycol Dimethacrylate Hydrogen-Ion Concentration Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - metabolism Rabbits
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