HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV
Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-03, Vol.271 (5253), p.1291-1293 |
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| creator | Soto-Ramirez, Luis E. Renjifo, Boris McLane, Mary F. Marlink, Richard O'Hara, Carl Sutthent, Ruengpung Wasi, Chantapong Vithayasai, Prakong Vithayasai, Vicharn Apichartpiyakul, Chatchawann Auewarakul, Prasert Cruz, Victor Peña Chui, Dao-Shan Osathanondh, Rapin Mayer, Kenneth Lee, Tun-Hou Essex, Max |
| description | Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV. |
| doi_str_mv | 10.1126/science.271.5253.1291 |
| format | Article |
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Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.271.5253.1291</identifier><identifier>PMID: 8638113</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>AIDS ; AIDS/HIV ; Biological and medical sciences ; Cell Line ; Cells, Cultured ; Heterosexual transmission ; HIV ; HIV (Viruses) ; HIV 1 ; HIV Core Protein p24 - analysis ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - growth & development ; HIV-1 - isolation & purification ; Homosexuality ; Homosexuality, Male ; human immunodeficiency virus 1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Islets of Langerhans ; Langerhans cells ; Langerhans Cells - virology ; Macrophages - virology ; Male ; Medical sciences ; Monocytes - virology ; Sexual Behavior ; Sexually transmitted diseases ; Sexually Transmitted Diseases, Viral - transmission ; Sexually Transmitted Diseases, Viral - virology ; T lymphocytes ; T-Lymphocytes - virology ; Thailand ; Tropisms ; United States ; Virus Replication ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5253), p.1291-1293</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c689t-8ec9515c4ab6b8cb71c5982d77c437f83ac54ba6613d0bd5c8a4df888b26aa03</citedby><cites>FETCH-LOGICAL-c689t-8ec9515c4ab6b8cb71c5982d77c437f83ac54ba6613d0bd5c8a4df888b26aa03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2889495$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2889495$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3003638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8638113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soto-Ramirez, Luis E.</creatorcontrib><creatorcontrib>Renjifo, Boris</creatorcontrib><creatorcontrib>McLane, Mary F.</creatorcontrib><creatorcontrib>Marlink, Richard</creatorcontrib><creatorcontrib>O'Hara, Carl</creatorcontrib><creatorcontrib>Sutthent, Ruengpung</creatorcontrib><creatorcontrib>Wasi, Chantapong</creatorcontrib><creatorcontrib>Vithayasai, Prakong</creatorcontrib><creatorcontrib>Vithayasai, Vicharn</creatorcontrib><creatorcontrib>Apichartpiyakul, Chatchawann</creatorcontrib><creatorcontrib>Auewarakul, Prasert</creatorcontrib><creatorcontrib>Cruz, Victor Peña</creatorcontrib><creatorcontrib>Chui, Dao-Shan</creatorcontrib><creatorcontrib>Osathanondh, Rapin</creatorcontrib><creatorcontrib>Mayer, Kenneth</creatorcontrib><creatorcontrib>Lee, Tun-Hou</creatorcontrib><creatorcontrib>Essex, Max</creatorcontrib><title>HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.</description><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Heterosexual transmission</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV 1</subject><subject>HIV Core Protein p24 - analysis</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - growth & development</subject><subject>HIV-1 - isolation & purification</subject><subject>Homosexuality</subject><subject>Homosexuality, Male</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Islets of Langerhans</subject><subject>Langerhans cells</subject><subject>Langerhans Cells - virology</subject><subject>Macrophages - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monocytes - virology</subject><subject>Sexual Behavior</subject><subject>Sexually transmitted diseases</subject><subject>Sexually Transmitted Diseases, Viral - transmission</subject><subject>Sexually Transmitted Diseases, Viral - virology</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - virology</subject><subject>Thailand</subject><subject>Tropisms</subject><subject>United States</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0k2L2zAQBmBTWrbptv-gCz6UbQ_rVB-WLR3T0CaB0Bwa9ipkeezVYlupZNPtv69MTCAQaNBBoHlGDMwbRXcYzTEm2VevDXQa5iTHc0YYnWMi8KtohpFgiSCIvo5mCNEs4Shnb6N33j8jFGqC3kQ3PKMcYzqLduvNY4LjrepqcE-q85_jJTRNvHf2YHwbL7y32qgeyviP6Z_iNfTgrIeXQY0oNLTGe2O72FZx-Ot99KZSjYcP030b7X983y_XyXa32iwX20RnXPQJBy0YZjpVRVZwXeRYM8FJmec6pXnFqdIsLVSWYVqiomSaq7SsOOcFyZRC9Da6P357cPb3AL6XYQwdBlcd2MHLnCMmBBf_hThHBPEsDfDhCGvVgDRdZXundA0dONXYDioTnheYY0I4HwdILvBwSmiNvuS_nPlAenjpazV4Lze_fl5Nd49X02-raylfbc_owyWqbdNADTLscbk74-zIdQiGd1DJgzOtcn8lRnKMqpyiKkNU5RhVOUY19N1NqxmKFspT15TNUP801ZXXqqlC2LTxJ0bHcFMe2Mcje_a9dadyGE2kgtF_fl32uA</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Soto-Ramirez, Luis E.</creator><creator>Renjifo, Boris</creator><creator>McLane, Mary F.</creator><creator>Marlink, Richard</creator><creator>O'Hara, Carl</creator><creator>Sutthent, Ruengpung</creator><creator>Wasi, Chantapong</creator><creator>Vithayasai, Prakong</creator><creator>Vithayasai, Vicharn</creator><creator>Apichartpiyakul, Chatchawann</creator><creator>Auewarakul, Prasert</creator><creator>Cruz, Victor Peña</creator><creator>Chui, Dao-Shan</creator><creator>Osathanondh, Rapin</creator><creator>Mayer, Kenneth</creator><creator>Lee, Tun-Hou</creator><creator>Essex, Max</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV</title><author>Soto-Ramirez, Luis E. ; Renjifo, Boris ; McLane, Mary F. ; Marlink, Richard ; O'Hara, Carl ; Sutthent, Ruengpung ; Wasi, Chantapong ; Vithayasai, Prakong ; Vithayasai, Vicharn ; Apichartpiyakul, Chatchawann ; Auewarakul, Prasert ; Cruz, Victor Peña ; Chui, Dao-Shan ; Osathanondh, Rapin ; Mayer, Kenneth ; Lee, Tun-Hou ; Essex, Max</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c689t-8ec9515c4ab6b8cb71c5982d77c437f83ac54ba6613d0bd5c8a4df888b26aa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Heterosexual transmission</topic><topic>HIV</topic><topic>HIV (Viruses)</topic><topic>HIV 1</topic><topic>HIV Core Protein p24 - analysis</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - growth & development</topic><topic>HIV-1 - isolation & purification</topic><topic>Homosexuality</topic><topic>Homosexuality, Male</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infections</topic><topic>Islets of Langerhans</topic><topic>Langerhans cells</topic><topic>Langerhans Cells - virology</topic><topic>Macrophages - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monocytes - virology</topic><topic>Sexual Behavior</topic><topic>Sexually transmitted diseases</topic><topic>Sexually Transmitted Diseases, Viral - transmission</topic><topic>Sexually Transmitted Diseases, Viral - virology</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - virology</topic><topic>Thailand</topic><topic>Tropisms</topic><topic>United States</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soto-Ramirez, Luis E.</creatorcontrib><creatorcontrib>Renjifo, Boris</creatorcontrib><creatorcontrib>McLane, Mary F.</creatorcontrib><creatorcontrib>Marlink, Richard</creatorcontrib><creatorcontrib>O'Hara, Carl</creatorcontrib><creatorcontrib>Sutthent, Ruengpung</creatorcontrib><creatorcontrib>Wasi, Chantapong</creatorcontrib><creatorcontrib>Vithayasai, Prakong</creatorcontrib><creatorcontrib>Vithayasai, Vicharn</creatorcontrib><creatorcontrib>Apichartpiyakul, Chatchawann</creatorcontrib><creatorcontrib>Auewarakul, Prasert</creatorcontrib><creatorcontrib>Cruz, Victor Peña</creatorcontrib><creatorcontrib>Chui, Dao-Shan</creatorcontrib><creatorcontrib>Osathanondh, Rapin</creatorcontrib><creatorcontrib>Mayer, Kenneth</creatorcontrib><creatorcontrib>Lee, Tun-Hou</creatorcontrib><creatorcontrib>Essex, Max</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soto-Ramirez, Luis E.</au><au>Renjifo, Boris</au><au>McLane, Mary F.</au><au>Marlink, Richard</au><au>O'Hara, Carl</au><au>Sutthent, Ruengpung</au><au>Wasi, Chantapong</au><au>Vithayasai, Prakong</au><au>Vithayasai, Vicharn</au><au>Apichartpiyakul, Chatchawann</au><au>Auewarakul, Prasert</au><au>Cruz, Victor Peña</au><au>Chui, Dao-Shan</au><au>Osathanondh, Rapin</au><au>Mayer, Kenneth</au><au>Lee, Tun-Hou</au><au>Essex, Max</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>271</volume><issue>5253</issue><spage>1291</spage><epage>1293</epage><pages>1291-1293</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8638113</pmid><doi>10.1126/science.271.5253.1291</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5253), p.1291-1293 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78059989 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | AIDS AIDS/HIV Biological and medical sciences Cell Line Cells, Cultured Heterosexual transmission HIV HIV (Viruses) HIV 1 HIV Core Protein p24 - analysis HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - growth & development HIV-1 - isolation & purification Homosexuality Homosexuality, Male human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Islets of Langerhans Langerhans cells Langerhans Cells - virology Macrophages - virology Male Medical sciences Monocytes - virology Sexual Behavior Sexually transmitted diseases Sexually Transmitted Diseases, Viral - transmission Sexually Transmitted Diseases, Viral - virology T lymphocytes T-Lymphocytes - virology Thailand Tropisms United States Virus Replication Viruses |
| title | HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV |
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