A Case of Small Cell Carcinoma of the Uterine Cervix Presenting Cushing's Syndrome
A proportion of small cell carcinoma of the uterine cervix is known to secrete a neuroendocrine substance. However, cases presenting Cushing's syndrome due to ACTH secreted from a cervical small cell carcinoma are extremely rare. Here, we report a case of small cell carcinoma of the uterine cer...
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| Veröffentlicht in: | Gynecologic oncology 1996-06, Vol.61 (3), p.427-431 |
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| creator | Hashi, Akihiko Yasumizu, Takehiko Yoda, Ituo Kou, Tomoko Mizuno, Kaoruko Hirata, Syuji Kato, Junzo Katoh, Ryohei Inoue, Masaharu Kawaguchi, Akio Nakazato, Minoru Onaya, Tosimasa |
| description | A proportion of small cell carcinoma of the uterine cervix is known to secrete a neuroendocrine substance. However, cases presenting Cushing's syndrome due to ACTH secreted from a cervical small cell carcinoma are extremely rare. Here, we report a case of small cell carcinoma of the uterine cervix that ectopically secreted ACTH and presented Cushing's syndrome. A 42-year-old woman was initially admitted to the endocrine unit for investigation of ectopic ACTH syndrome. Serum cortisol and plasma ACTH levels were elevated with no diurnal variation. After gynecologic examination, her original disease was found to be a stage IIb cervical small cell carcinoma. She underwent a radical hysterectomy and pelvic lymphadenectomy. The entire tumor was excised and post-TNM classification was T2bN1M0. Immunohistochemically, tumor cells stained strongly for ACTH and chromogranin. Electron-microscopic pictures showed typical neurosecretory granules. Although plasma ACTH returned to normal after surgery, liver metastasis appeared during the course of postoperative irradiation. She died 9 months after operation in spite of vigorous systemic chemotherapy. |
| doi_str_mv | 10.1006/gyno.1996.0168 |
| format | Article |
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However, cases presenting Cushing's syndrome due to ACTH secreted from a cervical small cell carcinoma are extremely rare. Here, we report a case of small cell carcinoma of the uterine cervix that ectopically secreted ACTH and presented Cushing's syndrome. A 42-year-old woman was initially admitted to the endocrine unit for investigation of ectopic ACTH syndrome. Serum cortisol and plasma ACTH levels were elevated with no diurnal variation. After gynecologic examination, her original disease was found to be a stage IIb cervical small cell carcinoma. She underwent a radical hysterectomy and pelvic lymphadenectomy. The entire tumor was excised and post-TNM classification was T2bN1M0. Immunohistochemically, tumor cells stained strongly for ACTH and chromogranin. Electron-microscopic pictures showed typical neurosecretory granules. Although plasma ACTH returned to normal after surgery, liver metastasis appeared during the course of postoperative irradiation. She died 9 months after operation in spite of vigorous systemic chemotherapy.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.1996.0168</identifier><identifier>PMID: 8641627</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adrenocorticotropic Hormone - analysis ; Adrenocorticotropic Hormone - secretion ; Adult ; Biological and medical sciences ; Carcinoma, Small Cell - complications ; Carcinoma, Small Cell - diagnosis ; Carcinoma, Small Cell - pathology ; Carcinoma, Small Cell - secretion ; Carcinoma, Small Cell - therapy ; Chromogranins - analysis ; Cushing Syndrome - etiology ; Diagnosis, Differential ; Fatal Outcome ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Tumors ; Uterine Cervical Neoplasms - complications ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - secretion ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Gynecologic oncology, 1996-06, Vol.61 (3), p.427-431</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-e74cee14d79d5e989f387f73052e0a3af7179af13010eeb9f19d43d8a1117e8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/gyno.1996.0168$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3114620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8641627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashi, Akihiko</creatorcontrib><creatorcontrib>Yasumizu, Takehiko</creatorcontrib><creatorcontrib>Yoda, Ituo</creatorcontrib><creatorcontrib>Kou, Tomoko</creatorcontrib><creatorcontrib>Mizuno, Kaoruko</creatorcontrib><creatorcontrib>Hirata, Syuji</creatorcontrib><creatorcontrib>Kato, Junzo</creatorcontrib><creatorcontrib>Katoh, Ryohei</creatorcontrib><creatorcontrib>Inoue, Masaharu</creatorcontrib><creatorcontrib>Kawaguchi, Akio</creatorcontrib><creatorcontrib>Nakazato, Minoru</creatorcontrib><creatorcontrib>Onaya, Tosimasa</creatorcontrib><title>A Case of Small Cell Carcinoma of the Uterine Cervix Presenting Cushing's Syndrome</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>A proportion of small cell carcinoma of the uterine cervix is known to secrete a neuroendocrine substance. However, cases presenting Cushing's syndrome due to ACTH secreted from a cervical small cell carcinoma are extremely rare. Here, we report a case of small cell carcinoma of the uterine cervix that ectopically secreted ACTH and presented Cushing's syndrome. A 42-year-old woman was initially admitted to the endocrine unit for investigation of ectopic ACTH syndrome. Serum cortisol and plasma ACTH levels were elevated with no diurnal variation. After gynecologic examination, her original disease was found to be a stage IIb cervical small cell carcinoma. She underwent a radical hysterectomy and pelvic lymphadenectomy. The entire tumor was excised and post-TNM classification was T2bN1M0. Immunohistochemically, tumor cells stained strongly for ACTH and chromogranin. Electron-microscopic pictures showed typical neurosecretory granules. Although plasma ACTH returned to normal after surgery, liver metastasis appeared during the course of postoperative irradiation. She died 9 months after operation in spite of vigorous systemic chemotherapy.</description><subject>Adrenocorticotropic Hormone - analysis</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - complications</subject><subject>Carcinoma, Small Cell - diagnosis</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Carcinoma, Small Cell - secretion</subject><subject>Carcinoma, Small Cell - therapy</subject><subject>Chromogranins - analysis</subject><subject>Cushing Syndrome - etiology</subject><subject>Diagnosis, Differential</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - complications</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - secretion</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVJSbZpr70VfAjpyZsZy9bHMZikLQRamuQsFHmUqKzlRPKG7r-vzC659aIBvc8MLw9jnxHWCCAuHndxWqPWYg0o1Du2QtBdLVSnj9gKQEOtmk6dsA85_wEADtgcs2MlWhSNXLHfl1VvM1WTr25Hu9lUPS2PTS7EabTL__xE1f1MKUQqaXoNf6tfiTLFOcTHqt_mpzK_5up2F4c0jfSRvfd2k-nTYZ6y--uru_57ffPz24_-8qZ2LW_nmmTriLAdpB460kp7rqSXHLqGwHLrJUptPZbGQPSgPeqh5YOyiChJET9l5_u7z2l62VKezRiyK_VtpGmbjVTQaS5EAdd70KUp50TePKcw2rQzCGaRaBaJZpFoFoll4cvh8vZhpOENP1gr-dkht9nZjU82upDfMI7YigYKpvYYFQuvgZLJLlB0NIREbjbDFP7X4B8M8YyU</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Hashi, Akihiko</creator><creator>Yasumizu, Takehiko</creator><creator>Yoda, Ituo</creator><creator>Kou, Tomoko</creator><creator>Mizuno, Kaoruko</creator><creator>Hirata, Syuji</creator><creator>Kato, Junzo</creator><creator>Katoh, Ryohei</creator><creator>Inoue, Masaharu</creator><creator>Kawaguchi, Akio</creator><creator>Nakazato, Minoru</creator><creator>Onaya, Tosimasa</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>A Case of Small Cell Carcinoma of the Uterine Cervix Presenting Cushing's Syndrome</title><author>Hashi, Akihiko ; Yasumizu, Takehiko ; Yoda, Ituo ; Kou, Tomoko ; Mizuno, Kaoruko ; Hirata, Syuji ; Kato, Junzo ; Katoh, Ryohei ; Inoue, Masaharu ; Kawaguchi, Akio ; Nakazato, Minoru ; Onaya, Tosimasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-e74cee14d79d5e989f387f73052e0a3af7179af13010eeb9f19d43d8a1117e8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenocorticotropic Hormone - analysis</topic><topic>Adrenocorticotropic Hormone - secretion</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - complications</topic><topic>Carcinoma, Small Cell - diagnosis</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Carcinoma, Small Cell - secretion</topic><topic>Carcinoma, Small Cell - therapy</topic><topic>Chromogranins - analysis</topic><topic>Cushing Syndrome - etiology</topic><topic>Diagnosis, Differential</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - complications</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - secretion</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashi, Akihiko</creatorcontrib><creatorcontrib>Yasumizu, Takehiko</creatorcontrib><creatorcontrib>Yoda, Ituo</creatorcontrib><creatorcontrib>Kou, Tomoko</creatorcontrib><creatorcontrib>Mizuno, Kaoruko</creatorcontrib><creatorcontrib>Hirata, Syuji</creatorcontrib><creatorcontrib>Kato, Junzo</creatorcontrib><creatorcontrib>Katoh, Ryohei</creatorcontrib><creatorcontrib>Inoue, Masaharu</creatorcontrib><creatorcontrib>Kawaguchi, Akio</creatorcontrib><creatorcontrib>Nakazato, Minoru</creatorcontrib><creatorcontrib>Onaya, Tosimasa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashi, Akihiko</au><au>Yasumizu, Takehiko</au><au>Yoda, Ituo</au><au>Kou, Tomoko</au><au>Mizuno, Kaoruko</au><au>Hirata, Syuji</au><au>Kato, Junzo</au><au>Katoh, Ryohei</au><au>Inoue, Masaharu</au><au>Kawaguchi, Akio</au><au>Nakazato, Minoru</au><au>Onaya, Tosimasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Small Cell Carcinoma of the Uterine Cervix Presenting Cushing's Syndrome</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>61</volume><issue>3</issue><spage>427</spage><epage>431</epage><pages>427-431</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>A proportion of small cell carcinoma of the uterine cervix is known to secrete a neuroendocrine substance. However, cases presenting Cushing's syndrome due to ACTH secreted from a cervical small cell carcinoma are extremely rare. Here, we report a case of small cell carcinoma of the uterine cervix that ectopically secreted ACTH and presented Cushing's syndrome. A 42-year-old woman was initially admitted to the endocrine unit for investigation of ectopic ACTH syndrome. Serum cortisol and plasma ACTH levels were elevated with no diurnal variation. After gynecologic examination, her original disease was found to be a stage IIb cervical small cell carcinoma. She underwent a radical hysterectomy and pelvic lymphadenectomy. The entire tumor was excised and post-TNM classification was T2bN1M0. Immunohistochemically, tumor cells stained strongly for ACTH and chromogranin. Electron-microscopic pictures showed typical neurosecretory granules. Although plasma ACTH returned to normal after surgery, liver metastasis appeared during the course of postoperative irradiation. She died 9 months after operation in spite of vigorous systemic chemotherapy.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8641627</pmid><doi>10.1006/gyno.1996.0168</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 1996-06, Vol.61 (3), p.427-431 |
| issn | 0090-8258 1095-6859 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenocorticotropic Hormone - analysis Adrenocorticotropic Hormone - secretion Adult Biological and medical sciences Carcinoma, Small Cell - complications Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - pathology Carcinoma, Small Cell - secretion Carcinoma, Small Cell - therapy Chromogranins - analysis Cushing Syndrome - etiology Diagnosis, Differential Fatal Outcome Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Tumors Uterine Cervical Neoplasms - complications Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - secretion Uterine Cervical Neoplasms - therapy |
| title | A Case of Small Cell Carcinoma of the Uterine Cervix Presenting Cushing's Syndrome |
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