Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone
THE probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presy...
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| Veröffentlicht in: | Nature (London) 1996-06, Vol.381 (6582), p.523-525 |
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| container_title | Nature (London) |
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| creator | Shigemoto, Ryuichi Kulik, Akos Roberts, J. David B. Ohishi, Hitoshi Nusser, Zoltan Kaneko, Takeshi Somogyi, Peter |
| description | THE probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic autoreceptors
1–3
. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target. |
| doi_str_mv | 10.1038/381523a0 |
| format | Article |
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. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/381523a0</identifier><identifier>PMID: 8632825</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anatomical correlates of behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Hippocampus - metabolism ; Hippocampus - ultrastructure ; Humanities and Social Sciences ; Interneurons - metabolism ; letter ; multidisciplinary ; Nervous system ; Neurons ; Phytohemagglutinins ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Pyramidal Cells - metabolism ; Pyramidal Cells - ultrastructure ; Rabbits ; Rats ; Rats, Wistar ; Receptor Aggregation ; Receptors, Metabotropic Glutamate - metabolism ; Receptors, Metabotropic Glutamate - ultrastructure ; Rodents ; Science ; Science (multidisciplinary) ; Synaptic Membranes - metabolism ; Synaptic Membranes - ultrastructure ; Synaptic Vesicles - metabolism ; Synaptic Vesicles - ultrastructure</subject><ispartof>Nature (London), 1996-06, Vol.381 (6582), p.523-525</ispartof><rights>Springer Nature Limited 1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jun 6, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-bb45176ce1379644cddbaeefad6bfeb8cb23bd755a70c9c25eeaea78d7eb1a663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/381523a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/381523a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3091930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8632825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigemoto, Ryuichi</creatorcontrib><creatorcontrib>Kulik, Akos</creatorcontrib><creatorcontrib>Roberts, J. David B.</creatorcontrib><creatorcontrib>Ohishi, Hitoshi</creatorcontrib><creatorcontrib>Nusser, Zoltan</creatorcontrib><creatorcontrib>Kaneko, Takeshi</creatorcontrib><creatorcontrib>Somogyi, Peter</creatorcontrib><title>Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic autoreceptors
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David B.</au><au>Ohishi, Hitoshi</au><au>Nusser, Zoltan</au><au>Kaneko, Takeshi</au><au>Somogyi, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-06-06</date><risdate>1996</risdate><volume>381</volume><issue>6582</issue><spage>523</spage><epage>525</epage><pages>523-525</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>THE probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic autoreceptors
1–3
. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8632825</pmid><doi>10.1038/381523a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-06, Vol.381 (6582), p.523-525 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78058415 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Guinea Pigs Hippocampus - metabolism Hippocampus - ultrastructure Humanities and Social Sciences Interneurons - metabolism letter multidisciplinary Nervous system Neurons Phytohemagglutinins Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Cells - metabolism Pyramidal Cells - ultrastructure Rabbits Rats Rats, Wistar Receptor Aggregation Receptors, Metabotropic Glutamate - metabolism Receptors, Metabotropic Glutamate - ultrastructure Rodents Science Science (multidisciplinary) Synaptic Membranes - metabolism Synaptic Membranes - ultrastructure Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure |
| title | Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone |
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