Mechanism of Simultaneous Iodination and Coupling Catalyzed by Thyroid Peroxidase

Thyroid peroxidase (TPO) simultaneously catalyzes two very different types of reaction in the thyroid gland—iodination and coupling. The present study addresses the mechanism of this simultaneous dual activity. Compound I, the two-electron oxidation product of TPO, exists in two different forms—an o...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1996-06, Vol.330 (1), p.24-32
Hauptverfasser:	Taurog, Alvin, Dorris, Martha L., Doerge, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome-c Peroxidase - metabolism Free Radicals Glucose Oxidase Goiter - metabolism Horseradish Peroxidase - metabolism Hydrogen-Ion Concentration Iodide Peroxidase - chemistry Iodide Peroxidase - metabolism Iodides - metabolism Kinetics Lactoperoxidase - metabolism Peroxidases - metabolism Serum Albumin, Bovine Spectrophotometry Swine Thyroglobulin - metabolism Thyroid Gland - enzymology
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