Serum hyaluronan concentrations predict survival in patients with chronic renal failure on maintenance haemodialysis
Malnutrition and wasting are common in chronic renal failure and are adverse prognostic features. The underlying mechanisms are complex and not fully understood. Hyaluronan is present in increased concentrations in chronic renal failure and may be associated with adverse features of chronic renal fa...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 1996, Vol.11 (1), p.98-100 |
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| creator | WOODROW, G TURNEY, J. H DAVISON, A. M COOPER, E. H |
| description | Malnutrition and wasting are common in chronic renal failure and are adverse prognostic features. The underlying mechanisms are complex and not fully understood. Hyaluronan is present in increased concentrations in chronic renal failure and may be associated with adverse features of chronic renal failure.
We have investigated the relationship of this abnormality to long-term survival. Outcome of 81 patients of median of 5.6 years (3.9-6.8) after measurement of hyaluronan was determined.
Survival analysis by the Cox regression model showed that increased concentrations of hyaluronan (P < 0.0001). There was also a weak but significant negative correlation between hyaluronan concentrations and serum albumin concentrations (rs = - 0.27, P = 0.02).
We conclude that serum hyaluronan is a strong independent predictor of long-term survival in CRF may reflect abnormal connective tissue metabolism in this condition. |
| doi_str_mv | 10.1093/ndt/11.1.98 |
| format | Article |
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We have investigated the relationship of this abnormality to long-term survival. Outcome of 81 patients of median of 5.6 years (3.9-6.8) after measurement of hyaluronan was determined.
Survival analysis by the Cox regression model showed that increased concentrations of hyaluronan (P < 0.0001). There was also a weak but significant negative correlation between hyaluronan concentrations and serum albumin concentrations (rs = - 0.27, P = 0.02).
We conclude that serum hyaluronan is a strong independent predictor of long-term survival in CRF may reflect abnormal connective tissue metabolism in this condition.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/11.1.98</identifier><identifier>PMID: 8649660</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: renal failure. Dialysis management ; Humans ; Hyaluronic Acid - blood ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - therapy ; Medical sciences ; Middle Aged ; Prognosis ; Regression Analysis ; Renal Dialysis ; Reproducibility of Results ; Serum Albumin - metabolism ; Survival Rate</subject><ispartof>Nephrology, dialysis, transplantation, 1996, Vol.11 (1), p.98-100</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-79917bd61d6b056ff0699894fff93d5922fba6283670f4755f5a79550984eeba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3013167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8649660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WOODROW, G</creatorcontrib><creatorcontrib>TURNEY, J. H</creatorcontrib><creatorcontrib>DAVISON, A. M</creatorcontrib><creatorcontrib>COOPER, E. H</creatorcontrib><title>Serum hyaluronan concentrations predict survival in patients with chronic renal failure on maintenance haemodialysis</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Malnutrition and wasting are common in chronic renal failure and are adverse prognostic features. The underlying mechanisms are complex and not fully understood. Hyaluronan is present in increased concentrations in chronic renal failure and may be associated with adverse features of chronic renal failure.
We have investigated the relationship of this abnormality to long-term survival. Outcome of 81 patients of median of 5.6 years (3.9-6.8) after measurement of hyaluronan was determined.
Survival analysis by the Cox regression model showed that increased concentrations of hyaluronan (P < 0.0001). There was also a weak but significant negative correlation between hyaluronan concentrations and serum albumin concentrations (rs = - 0.27, P = 0.02).
We conclude that serum hyaluronan is a strong independent predictor of long-term survival in CRF may reflect abnormal connective tissue metabolism in this condition.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Humans</subject><subject>Hyaluronic Acid - blood</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - mortality</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Renal Dialysis</subject><subject>Reproducibility of Results</subject><subject>Serum Albumin - metabolism</subject><subject>Survival Rate</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM9LwzAYhoMoc05PnoUcxIt0S5omaY4y_AUDD-o5pGlCI206k1TZf29kY6cPvuf5XvheAK4xWmIkyMq3aYXxEi9FfQLmuGKoKElNT8E8U1wgisQ5uIjxCyEkSs5nYFazSjCG5iC9mzANsNupfgqjVx7q0WvjU1DJjT7CbTCt0wnGKfy4H9VD5-E2s6xE-OtSB3WXD52GwfiMrXI5ycDRw0E5n_Iy58FOmWFsnep30cVLcGZVH83VYS7A59Pjx_ql2Lw9v64fNoUmFKWCC4F50zLcsgZRZi1iQtSistYK0lJRlrZRrKwJ48hWnFJLFRc0v1tXxjSKLMDdPncbxu_JxCQHF7Xpe-XNOEXJa0QxoTSL93tRhzHGYKzcBjeosJMYyf-OZe5YYiyxFHW2bw6xUzOY9ugeSs389sBV1Kq3ITfg4lEjCBPMOPkD9KGG5Q</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>WOODROW, G</creator><creator>TURNEY, J. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Humans</topic><topic>Hyaluronic Acid - blood</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - mortality</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Renal Dialysis</topic><topic>Reproducibility of Results</topic><topic>Serum Albumin - metabolism</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOODROW, G</creatorcontrib><creatorcontrib>TURNEY, J. H</creatorcontrib><creatorcontrib>DAVISON, A. M</creatorcontrib><creatorcontrib>COOPER, E. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WOODROW, G</au><au>TURNEY, J. H</au><au>DAVISON, A. M</au><au>COOPER, E. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum hyaluronan concentrations predict survival in patients with chronic renal failure on maintenance haemodialysis</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>1996</date><risdate>1996</risdate><volume>11</volume><issue>1</issue><spage>98</spage><epage>100</epage><pages>98-100</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Malnutrition and wasting are common in chronic renal failure and are adverse prognostic features. The underlying mechanisms are complex and not fully understood. Hyaluronan is present in increased concentrations in chronic renal failure and may be associated with adverse features of chronic renal failure.
We have investigated the relationship of this abnormality to long-term survival. Outcome of 81 patients of median of 5.6 years (3.9-6.8) after measurement of hyaluronan was determined.
Survival analysis by the Cox regression model showed that increased concentrations of hyaluronan (P < 0.0001). There was also a weak but significant negative correlation between hyaluronan concentrations and serum albumin concentrations (rs = - 0.27, P = 0.02).
We conclude that serum hyaluronan is a strong independent predictor of long-term survival in CRF may reflect abnormal connective tissue metabolism in this condition.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8649660</pmid><doi>10.1093/ndt/11.1.98</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 1996, Vol.11 (1), p.98-100 |
| issn | 0931-0509 1460-2385 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management Humans Hyaluronic Acid - blood Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - mortality Kidney Failure, Chronic - therapy Medical sciences Middle Aged Prognosis Regression Analysis Renal Dialysis Reproducibility of Results Serum Albumin - metabolism Survival Rate |
| title | Serum hyaluronan concentrations predict survival in patients with chronic renal failure on maintenance haemodialysis |
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