Inactive Zymogen and Highly Active Proteolytically Processed Membrane-Bound Forms of the Transglutaminase 1 Enzyme in Human Epidermal Keratinocytes

The transglutaminase 1 enzyme is important for the formation of a cornified cell envelope in terminally differentiating keratinocytes. We show here that it is present in low levels in proliferating foreskin or cultured epidermal cells as an inactive zymogen full length form of 106 kDa, of which >...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-04, Vol.221 (1), p.101-106
Hauptverfasser:	Steinert, Peter M., Chung, Soo-Il, Kim, Soo-Youl
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Membrane - metabolism Cells, Cultured Cytosol - metabolism DNA Primers Enzyme Precursors - metabolism Epidermis - enzymology Humans Hydrolysis Keratinocytes - enzymology Molecular Sequence Data Protein Processing, Post-Translational Transglutaminases - metabolism
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