Correction of severe thrombocytopenia with chloroquine in the primary antiphospholipid syndrome
We describe a patient with Primary Antiphospholipid Syndrome (PAPS) and severe throm bocytopenia with bleeding, in whom treatment with high dose steroids failed to maintain a sustained level of platelets following an initial short lived response. After several unsuc cessful attempts with Danazol and...
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| Veröffentlicht in: | Lupus 1996-02, Vol.5 (1), p.81-83 |
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| creator | Suarez, IM Diaz, RA Canela, D-Aguayo Pujol de la Llave, E. |
| description | We describe a patient with Primary Antiphospholipid Syndrome (PAPS) and severe throm bocytopenia with bleeding, in whom treatment with high dose steroids failed to maintain a sustained level of platelets following an initial short lived response. After several unsuc cessful attempts with Danazol and aspirin combined with low dose steroids, the platelets count rose following the administration of chloroquine and low dose steroids and remained in the normal range even when steroids were tapered. |
| doi_str_mv | 10.1177/096120339600500116 |
| format | Article |
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After several unsuc cessful attempts with Danazol and aspirin combined with low dose steroids, the platelets count rose following the administration of chloroquine and low dose steroids and remained in the normal range even when steroids were tapered.</description><subject>Adult</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Antiphospholipid Syndrome - drug therapy</subject><subject>Antirheumatic Agents - administration & dosage</subject><subject>Chloroquine - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Thrombocytopenia - complications</subject><subject>Thrombocytopenia - drug therapy</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYh4Moc06_gCDkpKe6pGmT5ijDfzDwoueSpm9tRtvUpFX27U1Z8SKMEBL4Pe-P5EHompJ7SoVYE8lpTBiTnJCUEEr5CVrSRIgoJPEpWk5ANBHn6ML7HSGEUckXaJHxhMeMLVG-sc6BHoztsK2wh29wgIfa2bawej_YHjqj8I8Zaqzrxjr7NZoOsOkCBLh3plVuj1U3mL62PuzG9KbEft-VoQMu0VmlGg9X87lCH0-P75uXaPv2_Lp52EaaSTlEjOqyAqmKrMriNCZUcwa6DEsIVYhwTUUsWZKSImO6VCKmTJBKlhJAKFGwFbo99PbTC8EPeWu8hqZRHdjR5yILhmQiAnh3HExSzigPzlYoPpDaWe8dVPn825ySfPKf__cfhm7m-rFoofwbmYWHfH3IvfqEfGdH1wUtxxp_Afqoj_c</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Suarez, IM</creator><creator>Diaz, RA</creator><creator>Canela, D-Aguayo</creator><creator>Pujol de la Llave, E.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Correction of severe thrombocytopenia with chloroquine in the primary antiphospholipid syndrome</title><author>Suarez, IM ; Diaz, RA ; Canela, D-Aguayo ; Pujol de la Llave, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-31cdfe9ab8f825201c63ecdcdc77ab7ecd57293450b83cda721370f9d9ee7a7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>Antiphospholipid Syndrome - drug therapy</topic><topic>Antirheumatic Agents - administration & dosage</topic><topic>Chloroquine - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Thrombocytopenia - complications</topic><topic>Thrombocytopenia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suarez, IM</creatorcontrib><creatorcontrib>Diaz, RA</creatorcontrib><creatorcontrib>Canela, D-Aguayo</creatorcontrib><creatorcontrib>Pujol de la Llave, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suarez, IM</au><au>Diaz, RA</au><au>Canela, D-Aguayo</au><au>Pujol de la Llave, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correction of severe thrombocytopenia with chloroquine in the primary antiphospholipid syndrome</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>5</volume><issue>1</issue><spage>81</spage><epage>83</epage><pages>81-83</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>We describe a patient with Primary Antiphospholipid Syndrome (PAPS) and severe throm bocytopenia with bleeding, in whom treatment with high dose steroids failed to maintain a sustained level of platelets following an initial short lived response. 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| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 1996-02, Vol.5 (1), p.81-83 |
| issn | 0961-2033 1477-0962 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78050947 |
| source | MEDLINE; Sage Journals |
| subjects | Adult Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - drug therapy Antirheumatic Agents - administration & dosage Chloroquine - administration & dosage Female Follow-Up Studies Humans Thrombocytopenia - complications Thrombocytopenia - drug therapy |
| title | Correction of severe thrombocytopenia with chloroquine in the primary antiphospholipid syndrome |
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