Endothelin-induced changes of second messengers in cultured human ciliary muscle cells

To characterize the pharmacology of endothelin-induced changes in phospholipase C (PLC) activity, intracellular calcium concentration ([Ca2+]i) and cyclic adenosine monophosphate (cAMP) in cultured human ciliary muscle (HCM) cells. Changes in PLC activity of HCM cells were determined by production o...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1996-05, Vol.37 (6), p.1058-1066
Hauptverfasser:	Matsumoto, S, Yorio, T, Magnino, PE, DeSantis, L, Pang, IH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Biological and medical sciences Calcium - metabolism Cells, Cultured Ciliary Body - drug effects Ciliary Body - metabolism Cyclic AMP - biosynthesis Cyclooxygenase Inhibitors - pharmacology Dinoprostone - metabolism Endothelins - pharmacology Eye and associated structures. Visual pathways and centers. Vision Fluorescent Dyes - metabolism Fundamental and applied biological sciences. Psychology Fura-2 - metabolism Humans Indomethacin - pharmacology Inositol Phosphates - biosynthesis Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Oligopeptides - pharmacology Receptors, Endothelin - drug effects Receptors, Endothelin - metabolism Second Messenger Systems Type C Phospholipases - metabolism Vasoconstrictor Agents - pharmacology Vertebrates: nervous system and sense organs Viper Venoms - pharmacology
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