Pharmacokinetic studies of 131I-Stevioside and its metabolites

131I-STEVIOSIDE (1.10 MBq) was injected i.v in Wistar male rats, in distribution in the body and metabolism were studied. The highest concentration of radioactivity was observed in the liver and in the small intestine after 10 and 120 minutes, respectively. At 2 h after injection, the radioactivity...

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Veröffentlicht in:	Nuclear medicine and biology 1996, Vol.23 (1), p.97-100
Hauptverfasser:	Cardoso, V.N., Barbosa, M.F., Muramoto, E., Mesquita, C.H., Almeida, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	131I-Stevioside Animals Biological and medical sciences Biotransformation Chromatography, High Pressure Liquid Diterpenes - metabolism Diterpenes, Kaurane Feces - chemistry General and cellular metabolism. Vitamins Glucosides - administration & dosage Glucosides - pharmacokinetics Injections, Intravenous Iodine Radioisotopes Male Medical sciences Metabolites Pharmacology. Drug treatments Rats Rats, Wistar Terpenes - administration & dosage Terpenes - pharmacokinetics Tissue Distribution Wistar rat
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Zusammenfassung:	131I-STEVIOSIDE (1.10 MBq) was injected i.v in Wistar male rats, in distribution in the body and metabolism were studied. The highest concentration of radioactivity was observed in the liver and in the small intestine after 10 and 120 minutes, respectively. At 2 h after injection, the radioactivity eliminated in the bile was 52.0% of the original dose. The results of RP-HPLC analysis of the bile showed that stevioside was degraded in vivo and that steviol appeared as a major metabolite. However, in the urine; RP-HPLC analysis did not show the presence of steviol.
ISSN:	0969-8051 1872-9614
DOI:	10.1016/0969-8051(95)02072-1