Enhancement of catalytic activities of serine proteases by tripeptides compounds

The tripeptide compounds, Glu-Arg-Pro-amide (ERPm), d-Pro-Thr-Trp-amide (dPTWm) and thioproline-Thr-Trp (tPTW), were obtained by screening of synthetic peptides for growth-inhibitory activity toward cultured transformed cells. The effects of these peptide compounds on proteases were investigated and...

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Veröffentlicht in:	FEBS letters 1996-05, Vol.386 (1), p.47-50
Hauptverfasser:	Hiwasa, Takaki, Ogawa, Sachiko, Kobayashi, Hisashi, Ike, Yoshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	4-methylcoumaryl-7-amide acetyllysine Amino Acid Sequence Boc carbobenzoxy Caseins - metabolism Chymotrypsin - drug effects Chymotrypsin - metabolism d-arginine d-glutamic acid d-Pro-Thr-Trp-amide d-proline d-threonine dimethylsulfoxide DMSO Dose-Response Relationship, Drug dPTWm Enzyme Stability ERPm Fibrinolysin - drug effects Fibrinolysin - metabolism Glu-Arg-Pro-amide half-maximal inhibition concentration IC50 LAPase leucine aminopeptidase MCA Molecular Sequence Data PBS Peptides - pharmacology phosphate-buffered saline Protease-stimulatory tripeptide PST Pyr pyroglutamyl Serine Endopeptidases - drug effects Serine Endopeptidases - metabolism Serine protease Suc succinyl sulfonated proline Synthetic tripeptide t-butyloxycarbonyl thioproline thioproline-Thr-Trp tPTW Trypsin - drug effects Trypsin - metabolism Urokinase-Type Plasminogen Activator - drug effects Urokinase-Type Plasminogen Activator - metabolism
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