Isolation of a gene essential for biosynthesis of the lipopeptide antibiotics plipastatin B1 and surfactin in Bacillus subtilis YB8

Bacillus subtilis YB8 was found to produce the lipopeptide antibiotics surfactin and plipastatin B1. A gene, lpa-8, required for the production of both lipopeptides was cloned from strain YB8. When this gene was inactivated in strain YB8, neither surfactin nor plipastatin B1 was produced. However, t...

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Veröffentlicht in:	Archives of microbiology 1996-04, Vol.165 (4), p.243-251
Hauptverfasser:	Tsuge, K, Ano, T, Shoda, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequences Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry antibiotic fungicides Antifungal Agents - chemistry antifungal antibotics Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - metabolism Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacteriology Base Sequence Biological and medical sciences biosynthesis cloning Cloning, Molecular comparisons DNA, Bacterial - genetics Fatty Acids - biosynthesis Fatty Acids - chemistry Fatty Acids - genetics Fundamental and applied biological sciences. Psychology genbank/d50562 genes Genes, Bacterial Genetics Lipopeptides lpa-8 gene Microbiology Molecular Sequence Data Molecular Structure nucleotide sequences Oligopeptides - biosynthesis Oligopeptides - chemistry Oligopeptides - genetics Peptides Peptides, Cyclic sequence alignment Sequence Homology, Amino Acid Transformation, Genetic
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