A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase (∗)

Phosphorylation and dephosphorylation of Tyr-530 in human c-Src (Tyr-527 in avian c-Src) is critical in regulating c-Src kinase activity. So far, it has not been possible to distinguish the active and inactive forms in vivo. We now report a new monoclonal antibody that selectively recognizes the act...

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Veröffentlicht in:	The Journal of biological chemistry 1996-03, Vol.271 (10), p.5680-5685
Hauptverfasser:	Kawakatsu, Hisaaki, Sakai, Takao, Takagaki, Yumiko, Shinoda, Yasuhiko, Saito, Masaki, Owada, M. Koji, Yano, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal Blood Platelets - enzymology Blotting, Western Cell Line CSK Tyrosine-Protein Kinase Embryo, Mammalian Fluorescent Antibody Technique Humans Immunohistochemistry Liver - embryology Liver - enzymology Mice Molecular Sequence Data Molecular Weight Peptide Fragments - chemistry Peptide Fragments - immunology Peptide Mapping Phosphopeptides - chemistry Phosphopeptides - isolation & purification Phosphoproteins - blood Phosphoproteins - chemistry Phosphoproteins - isolation & purification Phosphorylation Protein-Tyrosine Kinases - analysis Protein-Tyrosine Kinases - isolation & purification Protein-Tyrosine Kinases - metabolism Rats src-Family Kinases Tyrosine
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