Expression and Characterization of a Divalent Chimeric Anti‐Human CD3 Single Chain Antibody

Murine anti‐CD3 monoclonal antibodies (MoAbs) are used in clinical practice for immunosuppression. However, there are two major drawbacks to this treatment: the associated cytokine release syndrome and human anti‐mouse antibody response. To overcome these side‐effects, the authors generated a chimer...

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Veröffentlicht in:	Scandinavian journal of immunology 1996-02, Vol.43 (2), p.134-139
Hauptverfasser:	MA, SHENGLIN, THOMPSON, J., HU, HUAIZHONG, NEVILLE JR, D. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - pharmacology Antibody Affinity Antibody Specificity Base Sequence CD3 Complex - immunology Genetic Vectors Humans Immunoglobulin M - chemistry Immunoglobulin M - genetics Immunoglobulin M - isolation & purification Interferon-gamma - biosynthesis Lymphocyte Activation Mice Molecular Sequence Data Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - pharmacology T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - biosynthesis
Online-Zugang:	Volltext
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