Genistein Is a Natural Inhibitor of Hexose and Dehydroascorbic Acid Transport through the Glucose Transporter, GLUT1 (∗)

Genistein is a dietary-derived plant product that inhibits the activity of protein-tyrosine kinases. We show here that it is a potent inhibitor of the mammalian facilitative hexose transporter GLUT1. In human HL-60 cells, which express GLUT1, genistein inhibited the transport of dehydroascorbic acid...

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Veröffentlicht in:	The Journal of biological chemistry 1996-04, Vol.271 (15), p.8719-8724
Hauptverfasser:	Vera, Juan Carlos, Reyes, Alejandro M., Cárcamo, Juan G., Velásquez, Fernando V., Rivas, Coralia I., Zhang, Rong H., Strobel, Pablo, Iribarren, Rodrigo, Scher, Howard I., Slebe, Juan Carlos, Golde, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE ASCORBIQUE ACIDO ASCORBICO Amino Acids - metabolism Animals ANTIMETABOLITE ANTIMETABOLITOS Binding, Competitive Biological Transport CHO Cells Cricetinae CULTIVO DE CELULAS CULTURE DE CELLULE Dehydroascorbic Acid - metabolism Erythrocytes - metabolism FLAVONOIDE FLAVONOIDES Genistein Glucose Transporter Type 1 Hexoses - metabolism HL-60 Cells Humans Isoflavones - pharmacology Monosaccharide Transport Proteins - antagonists & inhibitors
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