(Aminoalkyl)indole Isothiocyanates as Potential Electrophilic Affinity Ligands for the Brain Cannabinoid Receptor

A series of (aminoalkyl)indole compounds, naphthalene analogs of pravadoline (1), has been shown to exhibit cannabinoid agonist activities such as antinociception in animals, inhibition of adenylate cyclase in brain membranes, and binding to the cannabinoid receptor. These pravadoline analogs were s...

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Veröffentlicht in:Journal of medicinal chemistry 1996-05, Vol.39 (10), p.1967-1974
Hauptverfasser: Yamada, Koichiro, Rice, Kenner C, Flippen-Anderson, Judith L, Eissenstat, Michael A, Ward, Susan J, Johnson, M. Ross, Howlett, Allyn C
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Sprache:eng
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