Vaccination of Pregnant Macaques Protects Newborns against Mucosal Simian Immunodeficiency Virus Infection

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIVmac following oral-conjunctival exposure and had persistently high viremia and rapid development of AIDS. In cont...

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Veröffentlicht in:	The Journal of infectious diseases 1996-06, Vol.173 (6), p.1327-1335
Hauptverfasser:	Van Rompay, Koen K. A., Otsyula, Moses G., Tarara, Ross P., Canfield, Don R., Berardi, Christopher J., McChesney, Michael B., Marthas, Marta L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - prevention & control AIDS AIDS/HIV Animals Animals, Newborn Antibodies Antibodies, Viral - blood Antivirals Biological and medical sciences CD4-CD8 Ratio Female HIV Humans Immunity, Maternally-Acquired - immunology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin Isotypes - blood Immunopathology Immunophenotyping Infants Infections Inoculation Macaca mulatta Major Articles Medical sciences Mouth Mucosa Neutralization Tests Newborns Pregnancy SAIDS Vaccines - administration & dosage SAIDS Vaccines - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - isolation & purification T-Lymphocytes, Cytotoxic - immunology Vaccination Viruses
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