Remifentanil versus alfentanil : Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers

Remifentanil is an esterase-metabolized opioid with a rapid clearance. The aim of this study was to contrast the pharmacokinetics and pharmacodynamics of remifentanil and alfentanil in healthy, adult male volunteers. Ten volunteers received infusions of remifentanil and alfentanil on separate study...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1996-04, Vol.84 (4), p.821-833
Hauptverfasser:	EGAN, T. D, MINTO, C. F, HERMANN, D. J, BARR, J, MUIR, K. T, SHAFER, S. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alfentanil - pharmacokinetics Alfentanil - pharmacology Analgesics Analgesics, Opioid - pharmacokinetics Biological and medical sciences Computer Simulation Cross-Over Studies Dose-Response Relationship, Drug Electroencephalography - drug effects Humans Male Medical sciences Models, Biological Neuropharmacology Pharmacology. Drug treatments Piperidines - pharmacokinetics Piperidines - pharmacology Remifentanil
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