Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides:  Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-Monophosphates

The decomposition pathways and kinetics in various biological media and the in vitro anti-HIV-1 and anti-HIV-2 activities of four derivatives of the 5‘-mononucleotide of isoddA incorporating carboxylate esterase-labile transient phosphate protecting groups are reported and compared:  namely, two mon...

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