DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma

DPC4, a candidate tumor suppressor gene, was identified recently at chromosome 18q21.1. Frequent homozygous deletion or mutations of the gene were observed in pancreatic carcinomas. To investigate the role of this gene in head and neck squamous cell carcinomas (HNSCCs), we examined 16 HNSCC cell lin...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (11), p.2519-2521
Hauptverfasser:	SE KYU KIM, FAN, Y, PAPADIMITRAKOPOULOU, V, CLAYMAN, G, HITTELMAN, W. N, WAUN KI HONG, LOTAN, R, MAO, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Carcinoma, Squamous Cell - genetics Chromosomes, Human, Pair 18 DNA Primers - chemistry DNA-Binding Proteins Genes, Tumor Suppressor Genetic Markers Head and Neck Neoplasms - genetics Heterozygote Humans Medical sciences Microsatellite Repeats Molecular Sequence Data Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Proteins - genetics Sequence Deletion Smad4 Protein Trans-Activators Tumors
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