Heavy chain dominance in the binding of DNA by a lupus mouse monoclonal autoantibody

Antibodies H241 and 2C10 are lupus mouse IgG autoantibodies that bind native DNA. In previous experiments, oligonucleotide antigens affinity-labeled both H and L chains of H241 but only the H chain of antibody 2C10. Primary structures of the V regions of the 2C10 H and L chains and the H241 L chain,...

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Veröffentlicht in:	Molecular immunology 1996-02, Vol.33 (2), p.197-210
Hauptverfasser:	Jang, Young-Ju, Lecerf, Jean-Michel, David Stollar, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Antinuclear - genetics Antibodies, Antinuclear - metabolism Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Autoantibodies B-DNA B-Lymphocytes - immunology Base Sequence cDNA Cloning, Molecular DNA DNA - immunology DNA - metabolism DNA Primers - genetics Escherichia coli - genetics Immunoglobulin Fab Fragments - genetics Immunoglobulin Fab Fragments - metabolism Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Mice Molecular Sequence Data MRL-lpr Polymerase Chain Reaction Single chain Fv Z-DNA
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