An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1
Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1$^{-/-}$ mice show...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-05, Vol.272 (5263), p.892-895 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Xanthoudakis, Steven Joao P. B. Viola Karen T. Y. Shaw Luo, Chun Wallace, James D. Bozza, Patricia T. Curran, Tom Rao, Anjana |
| description | Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1$^{-/-}$ mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1$^{-/-}$ mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response. |
| doi_str_mv | 10.1126/science.272.5263.892 |
| format | Article |
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B. Viola ; Karen T. Y. Shaw ; Luo, Chun ; Wallace, James D. ; Bozza, Patricia T. ; Curran, Tom ; Rao, Anjana</creator><creatorcontrib>Xanthoudakis, Steven ; Joao P. B. Viola ; Karen T. Y. Shaw ; Luo, Chun ; Wallace, James D. ; Bozza, Patricia T. ; Curran, Tom ; Rao, Anjana</creatorcontrib><description>Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1$^{-/-}$ mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1$^{-/-}$ mice. 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Biological and molecular evolution ; Hypersensitivity - immunology ; Immune response ; Immunity ; Immunity (Disease) ; Immunoglobulin E - biosynthesis ; Immunologic Memory ; Individualized Instruction ; Leishmania major - immunology ; Lymphocyte Activation ; Mice ; Molecular Sequence Data ; NFATC Transcription Factors ; Nuclear Proteins ; Ova ; Ovalbumin - immunology ; Physiological aspects ; Rodents ; Spleen cells ; T lymphocytes ; T-Lymphocytes - immunology ; Transcription (Genetics) ; Transcription Factors - genetics ; Transcription Factors - physiology ; Vertebrata</subject><ispartof>Science (American Association for the Advancement of Science), 1996-05, Vol.272 (5263), p.892-895</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science May 10, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c744t-7f1a8658cd7ebdc70cfce61b3227a11267e754986c72c928aa877caaca39f0193</citedby><cites>FETCH-LOGICAL-c744t-7f1a8658cd7ebdc70cfce61b3227a11267e754986c72c928aa877caaca39f0193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2890222$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2890222$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2883,2884,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3077662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8629027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xanthoudakis, Steven</creatorcontrib><creatorcontrib>Joao P. 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In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1$^{-/-}$ mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response.</description><subject>Alleles</subject><subject>Allergy</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>DNA</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Eosinophils</subject><subject>Eosinophils - immunology</subject><subject>Feedback (Response)</subject><subject>Fundamental and applied biological sciences. 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Shaw ; Luo, Chun ; Wallace, James D. ; Bozza, Patricia T. ; Curran, Tom ; Rao, Anjana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c744t-7f1a8658cd7ebdc70cfce61b3227a11267e754986c72c928aa877caaca39f0193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alleles</topic><topic>Allergy</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antigens, Protozoan - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>DNA</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Eosinophils</topic><topic>Eosinophils - immunology</topic><topic>Feedback (Response)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Targeting</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic transcription</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Hypersensitivity - immunology</topic><topic>Immune response</topic><topic>Immunity</topic><topic>Immunity (Disease)</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Immunologic Memory</topic><topic>Individualized Instruction</topic><topic>Leishmania major - immunology</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>NFATC Transcription Factors</topic><topic>Nuclear Proteins</topic><topic>Ova</topic><topic>Ovalbumin - immunology</topic><topic>Physiological aspects</topic><topic>Rodents</topic><topic>Spleen cells</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Transcription (Genetics)</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xanthoudakis, Steven</creatorcontrib><creatorcontrib>Joao P. 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Unexpectedly, cells from NFAT1$^{-/-}$ mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1$^{-/-}$ mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8629027</pmid><doi>10.1126/science.272.5263.892</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-05, Vol.272 (5263), p.892-895 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78034669 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Alleles Allergy Amino Acid Sequence Amino acids Animals Antigens, Protozoan - immunology Biological and medical sciences Cell Line Classical genetics, quantitative genetics, hybrids Cytokines Cytokines - biosynthesis DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Eosinophils Eosinophils - immunology Feedback (Response) Fundamental and applied biological sciences. Psychology Gene Targeting Genes Genetic aspects Genetic transcription Genetics of eukaryotes. Biological and molecular evolution Hypersensitivity - immunology Immune response Immunity Immunity (Disease) Immunoglobulin E - biosynthesis Immunologic Memory Individualized Instruction Leishmania major - immunology Lymphocyte Activation Mice Molecular Sequence Data NFATC Transcription Factors Nuclear Proteins Ova Ovalbumin - immunology Physiological aspects Rodents Spleen cells T lymphocytes T-Lymphocytes - immunology Transcription (Genetics) Transcription Factors - genetics Transcription Factors - physiology Vertebrata |
| title | An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A01%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Enhanced%20Immune%20Response%20in%20Mice%20Lacking%20the%20Transcription%20Factor%20NFAT1&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Xanthoudakis,%20Steven&rft.date=1996-05-10&rft.volume=272&rft.issue=5263&rft.spage=892&rft.epage=895&rft.pages=892-895&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.272.5263.892&rft_dat=%3Cgale_proqu%3EA18311952%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213553846&rft_id=info:pmid/8629027&rft_galeid=A18311952&rft_jstor_id=2890222&rfr_iscdi=true |