Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q
The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur frequently on chromosome 22q in human ovarian cancer. In this study, 110 sporadic ovarian tumors were analyzed using 8 polymorphic loci to define a minimum region of loss. Fifty...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1996-02, Vol.56 (4), p.719-721 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | BRYAN, E. J WATSON, R. H DAVIS, M HITCHCOCK, A FOULKES, W. D CAMPBELL, I. G |
| description | The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur frequently on chromosome 22q in human ovarian cancer. In this study, 110 sporadic ovarian tumors were analyzed using 8 polymorphic loci to define a minimum region of loss. Fifty-eight (53%) tumors showed loss of heterozygosity, and of these 6 exhibited partial loss, enabling the identification of two candidate tumor suppressor gene loci. One region, of less than 0.5 cM, is flanked by D22S284 and CYP2D, and a second region lies distal to D22S276. Analysis of loss of heterozygosity with respect to grade and stage suggests that chromosome 22q loss of heterozygosity is of more relevance in tumor progression rather than initiation. |
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J ; WATSON, R. H ; DAVIS, M ; HITCHCOCK, A ; FOULKES, W. D ; CAMPBELL, I. G</creator><creatorcontrib>BRYAN, E. J ; WATSON, R. H ; DAVIS, M ; HITCHCOCK, A ; FOULKES, W. D ; CAMPBELL, I. G</creatorcontrib><description>The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur frequently on chromosome 22q in human ovarian cancer. In this study, 110 sporadic ovarian tumors were analyzed using 8 polymorphic loci to define a minimum region of loss. Fifty-eight (53%) tumors showed loss of heterozygosity, and of these 6 exhibited partial loss, enabling the identification of two candidate tumor suppressor gene loci. One region, of less than 0.5 cM, is flanked by D22S284 and CYP2D, and a second region lies distal to D22S276. Analysis of loss of heterozygosity with respect to grade and stage suggests that chromosome 22q loss of heterozygosity is of more relevance in tumor progression rather than initiation.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8631002</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; Chromosome Deletion ; Chromosome Mapping ; Chromosomes, Human, Pair 22 ; Cytochrome P-450 Enzyme System - genetics ; Endometrial Neoplasms - genetics ; Endometrial Neoplasms - pathology ; Female ; Female genital diseases ; Genes, Tumor Suppressor ; Genetic Markers ; Gynecology. Andrology. 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Analysis of loss of heterozygosity with respect to grade and stage suggests that chromosome 22q loss of heterozygosity is of more relevance in tumor progression rather than initiation.</description><subject>Biological and medical sciences</subject><subject>Chromosome Deletion</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 22</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic Markers</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - classification</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1LxDAQDaKs6-pPEHIQT1aSNGnSo6yfsKKgHjyVNJ3sVtqmm7Qu-uuNWIRh3gzvzYN5e2hORaoSybnYR3NCiEoEl-wQHYXwEVdBiZihmcpSSgibo93KGd3U33qoXYedxTr2T-3riEZ3BjwextZ5HMa-9xBCHNfQAR4c1phcisQ8Yg_r3-sShh1Ah68Ze2GKR6sKL9-f2fUFjqzZeNe64FrAjG2P0YHVTYCTCRfo7fbmdXmfrJ7uHpZXq2TDMjkk2mhuZMk4FTI-JgXnKQEjRSW5VUBpLFqVOWEVVUpmTFtuBZgScs1SatMFOv_z7b3bjhCGoq2DgabRHbgxFFKRlLMYxwKdTsKxbKEqel-32n8VU1KRP5t4HWJi1sdw6vAvY3nOpczSH4L5cCc</recordid><startdate>19960215</startdate><enddate>19960215</enddate><creator>BRYAN, E. 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Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - classification</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRYAN, E. J</creatorcontrib><creatorcontrib>WATSON, R. H</creatorcontrib><creatorcontrib>DAVIS, M</creatorcontrib><creatorcontrib>HITCHCOCK, A</creatorcontrib><creatorcontrib>FOULKES, W. D</creatorcontrib><creatorcontrib>CAMPBELL, I. 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One region, of less than 0.5 cM, is flanked by D22S284 and CYP2D, and a second region lies distal to D22S276. Analysis of loss of heterozygosity with respect to grade and stage suggests that chromosome 22q loss of heterozygosity is of more relevance in tumor progression rather than initiation.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8631002</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1996-02, Vol.56 (4), p.719-721 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Biological and medical sciences Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 22 Cytochrome P-450 Enzyme System - genetics Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Female Female genital diseases Genes, Tumor Suppressor Genetic Markers Gynecology. Andrology. Obstetrics Humans Medical sciences Neoplasm Staging Ovarian Neoplasms - classification Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Polymerase Chain Reaction Polymorphism, Genetic Tumors |
| title | Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q |
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