Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis
To investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-α (TNF-α), interleukin (IL) IL-6, IL-8, and IL-10. Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment...
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| Veröffentlicht in: | Fertility and sterility 1996-06, Vol.65 (6), p.1125-1129 |
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| container_title | Fertility and sterility |
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| creator | Braun, Donald P. Gebel, Howard House, Robert Rana, Nasir Dmowski, W. Paul |
| description | To investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-α (TNF-α), interleukin (IL) IL-6, IL-8, and IL-10.
Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay.
Institute for the Study and Treatment of Endometriosis and university-based re-search laboratories.
Fertile controls, n = 10; women with endometriosis, n = 20.
None.
Basal synthesis of TNF-α, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-α by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10.
These data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease. |
| doi_str_mv | 10.1016/S0015-0282(16)58325-3 |
| format | Article |
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Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay.
Institute for the Study and Treatment of Endometriosis and university-based re-search laboratories.
Fertile controls, n = 10; women with endometriosis, n = 20.
None.
Basal synthesis of TNF-α, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-α by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10.
These data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)58325-3</identifier><identifier>PMID: 8641484</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; cytokines ; Cytokines - biosynthesis ; endometriosis ; Endometriosis - blood ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Interleukin-10 - biosynthesis ; Interleukin-6 - biosynthesis ; Interleukin-8 - biosynthesis ; Lipopolysaccharides - pharmacology ; Medical sciences ; Monocytes ; Monocytes - metabolism ; Non tumoral diseases ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Fertility and sterility, 1996-06, Vol.65 (6), p.1125-1129</ispartof><rights>1996 American Society for Reproductive Medicine</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-7a197e33915350f314b82a9f633774b169fee5583f678f23a4e84b608bbd57643</citedby><cites>FETCH-LOGICAL-c488t-7a197e33915350f314b82a9f633774b169fee5583f678f23a4e84b608bbd57643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)58325-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3111312$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8641484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, Donald P.</creatorcontrib><creatorcontrib>Gebel, Howard</creatorcontrib><creatorcontrib>House, Robert</creatorcontrib><creatorcontrib>Rana, Nasir</creatorcontrib><creatorcontrib>Dmowski, W. Paul</creatorcontrib><title>Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-α (TNF-α), interleukin (IL) IL-6, IL-8, and IL-10.
Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay.
Institute for the Study and Treatment of Endometriosis and university-based re-search laboratories.
Fertile controls, n = 10; women with endometriosis, n = 20.
None.
Basal synthesis of TNF-α, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-α by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10.
These data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease.</description><subject>Biological and medical sciences</subject><subject>cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>endometriosis</subject><subject>Endometriosis - blood</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Medical sciences</subject><subject>Monocytes</subject><subject>Monocytes - metabolism</subject><subject>Non tumoral diseases</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEUhYMoYzv6CANZiOiiNLfyU-mVDIN_MOBidB1SqRs6TlVSJmml397MdNNbVyGc757kfoRcAXsPDNSHO8ZAdqzX_VtQ76Tmvez4E7IBKVUnleRPyeaMPCcvSvnFGFMw9BfkQisBQosNub9bU6w2YtoXauNEQ5z2DidaDrHusIRCk6fuUNN9iFjoeKAr5rDuMNuZjnNKE11STI1oaYh0tTVgrIX-DXVHMU5pwZpDak0vyTNv54KvTucl-fn504-br93t9y_fbq5vOye0rt1gYTsg51uQXDLPQYy6t1uvOB8GMYLaekTZFvZq0L7nVqAWo2J6HCc5KMEvyZtj75rT7z2WapZQHM7zcU0zaNaqpGygPIIup1IyerPmsNh8MMDMg2TzKNk8GDTt9ijZ8DZ3dXpgPy44nadOVlv--pTb4uzss40ulDPGAYBD37CPRwybjD8BsymuuWv2Q0ZXzZTCfz7yD0Ubmdo</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Braun, Donald P.</creator><creator>Gebel, Howard</creator><creator>House, Robert</creator><creator>Rana, Nasir</creator><creator>Dmowski, W. Paul</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis</title><author>Braun, Donald P. ; Gebel, Howard ; House, Robert ; Rana, Nasir ; Dmowski, W. Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-7a197e33915350f314b82a9f633774b169fee5583f678f23a4e84b608bbd57643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>endometriosis</topic><topic>Endometriosis - blood</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Medical sciences</topic><topic>Monocytes</topic><topic>Monocytes - metabolism</topic><topic>Non tumoral diseases</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Donald P.</creatorcontrib><creatorcontrib>Gebel, Howard</creatorcontrib><creatorcontrib>House, Robert</creatorcontrib><creatorcontrib>Rana, Nasir</creatorcontrib><creatorcontrib>Dmowski, W. Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Donald P.</au><au>Gebel, Howard</au><au>House, Robert</au><au>Rana, Nasir</au><au>Dmowski, W. Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>65</volume><issue>6</issue><spage>1125</spage><epage>1129</epage><pages>1125-1129</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-α (TNF-α), interleukin (IL) IL-6, IL-8, and IL-10.
Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay.
Institute for the Study and Treatment of Endometriosis and university-based re-search laboratories.
Fertile controls, n = 10; women with endometriosis, n = 20.
None.
Basal synthesis of TNF-α, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-α by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10.
These data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8641484</pmid><doi>10.1016/S0015-0282(16)58325-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1996-06, Vol.65 (6), p.1125-1129 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78033755 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences cytokines Cytokines - biosynthesis endometriosis Endometriosis - blood Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Interleukin-10 - biosynthesis Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Lipopolysaccharides - pharmacology Medical sciences Monocytes Monocytes - metabolism Non tumoral diseases Tumor Necrosis Factor-alpha - biosynthesis |
| title | Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis |
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