Photoaffinity labeling of the human substance P (neurokinin-1) receptor with [3H2]azido-CP-96,345, a photoreactive derivative of a nonpeptide antagonist

An azido derivative of [3H2](2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl) methyl)-1-azabicyclo[2.2.2]octon-3-amine (CP-96,345), a potent nonpeptide antagonist of the substance P (SP) (neurokinin-1) receptor, was synthesized and shown to have an affinity for the human SP receptor similar to th...

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Veröffentlicht in:	Molecular pharmacology 1996-05, Vol.49 (5), p.808-813
Hauptverfasser:	D MacDonald, S C Silberman, J A Lowe, 3rd, S E Drozda, S E Leeman, N D Boyd
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Azides Binding Sites Binding, Competitive Biphenyl Compounds - chemistry CHO Cells Cricetinae Humans Hypnotics and Sedatives - chemistry Neurokinin-1 Receptor Antagonists Photochemistry Receptors, Neurokinin-1 - chemistry Recombinant Proteins
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