[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

: The potent noncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist [3H]MK‐801 bound with nanomolar affinity to rat brain membranes in a reversible, saturable, and stereospecific manner. The affinity of [3H]‐MK‐801 was considerably higher in 5 mM Tris‐HCl (pH 7.4) than in previous studies us...

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Veröffentlicht in:	Journal of neurochemistry 1988-01, Vol.50 (1), p.274-281
Hauptverfasser:	Wong, Erik H. F., Knight, Antony R., Woodruff, Geoffrey N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants Biological and medical sciences Brain - metabolism Cations, Divalent Cell Membrane - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Dibenzocycloheptenes - metabolism Dizocilpine Maleate Fundamental and applied biological sciences. Psychology Kinetics Male NMDA receptors Noncompetitive antagonists Phenazocine - analogs & derivatives Phenazocine - metabolism Phencyclidine Phencyclidine - analogs & derivatives Phencyclidine - metabolism Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - metabolism Tissue Distribution Tritium Vertebrates: nervous system and sense organs σ Opioid
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