IgG Antibody to Pneumococcal Capsular Polysaccharide in Human Immunodeficiency Virus-Infected Subjects: Persistence of Antibody in Responders, Revaccination in Nonresponders, and Relationship of Immunoglobulin Allotype to Response
Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classifi...
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| Veröffentlicht in: | The Journal of infectious diseases 1996-06, Vol.173 (6), p.1347-1353 |
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| container_title | The Journal of infectious diseases |
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| creator | Rodriguez-Barradas, Maria C. Groover, Jean E. Lacke, Christine E. Gump, Dieter W. Lahart, Christopher J. Pandey, Janardan P. Musher, Daniel M. |
| description | Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ⩾1 µ/mL for ⩾3 of 5 PPS [high] or for ⩽1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ⩾1 µg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination. |
| doi_str_mv | 10.1093/infdis/173.6.1347 |
| format | Article |
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Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ⩾1 µ/mL for ⩾3 of 5 PPS [high] or for ⩽1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ⩾1 µg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/173.6.1347</identifier><identifier>PMID: 8648206</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; AIDS/HIV ; Antibodies ; Antibodies, Bacterial - blood ; Antigens, Bacterial ; Bacterial Capsules - immunology ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - immunology ; Biological and medical sciences ; Dosage ; HIV ; HIV Infections - immunology ; human immunodeficiency virus ; Humans ; Immunization ; Immunization Schedule ; Immunization, Secondary ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin allotypes ; Immunoglobulin Allotypes - blood ; Immunoglobulin G - blood ; Immunopathology ; Major Articles ; Male ; Medical sciences ; Middle Aged ; Pneumococcal Infections - prevention & control ; Pneumococcal vaccine ; Pneumococcal Vaccines ; Polysaccharides ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Transponders ; Vaccination</subject><ispartof>The Journal of infectious diseases, 1996-06, Vol.173 (6), p.1347-1353</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>1996 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-f6f54a5a14d96fad382741472b62ed9b8ea12c2faaed9bd8cc85d04942dbeb793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30128144$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30128144$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3089749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8648206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez-Barradas, Maria C.</creatorcontrib><creatorcontrib>Groover, Jean E.</creatorcontrib><creatorcontrib>Lacke, Christine E.</creatorcontrib><creatorcontrib>Gump, Dieter W.</creatorcontrib><creatorcontrib>Lahart, Christopher J.</creatorcontrib><creatorcontrib>Pandey, Janardan P.</creatorcontrib><creatorcontrib>Musher, Daniel M.</creatorcontrib><title>IgG Antibody to Pneumococcal Capsular Polysaccharide in Human Immunodeficiency Virus-Infected Subjects: Persistence of Antibody in Responders, Revaccination in Nonresponders, and Relationship of Immunoglobulin Allotype to Response</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ⩾1 µ/mL for ⩾3 of 5 PPS [high] or for ⩽1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ⩾1 µg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.</description><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial</subject><subject>Bacterial Capsules - immunology</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>Dosage</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunization, Secondary</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin allotypes</subject><subject>Immunoglobulin Allotypes - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunopathology</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal vaccine</subject><subject>Pneumococcal Vaccines</subject><subject>Polysaccharides</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Transponders</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAYRiMEKqXwACyQLIRYkalv48TsRiPojChlKBehbizHdlpPEzvYCWJemOfAIUNbsWEVR-f8n235y7KnCM4Q5OTYulrbeIwKMmMzRGhxLztEc1LkjCFyPzuEEOMclZw_zB7FuIUQUsKKg-ygZLTEkB1mv9aXJ2Dhelt5vQO9BxtnhtYrr5RswFJ2cWhkABvf7KJU6koGqw2wDqyGVjqwbtvBeW1qq6xxage-2jDEfO1qo3qjwaeh2qZVfA02JkQb-yQZ4OvbLVPUuYmddzoJr9L6R9rGOtlb70Z45l24w6XTyWn-4HhluzFrOsRl46uhSROLpvH9rjPjbaboaB5nD2rZRPNk_z3Kvrx983m5yk8_nKyXi9Nc0ZL1ec3qOZVziajmrJaalLigiBa4YthoXpVGIqxwLeX4p0ulyrmGlFOsK1MVnBxlL6fcLvjvg4m9aG1UpmmkM36IoighQRiT_4qIwTmBCCfx-T_i1g_BpUuIlMNxiThKEpokFXyMwdSiC7aVYScQFGNTxNQUkZoimBibkmae7YOHqjX6ZmJfjcRf7LmMqQt1kE6lhL8agSUvKL-N2cbehzsYpaNRmng-8fHxf95wGa4FK0gxF6tvF2L17vyCvz_7KDbkN-Hr5zw</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Rodriguez-Barradas, Maria C.</creator><creator>Groover, Jean E.</creator><creator>Lacke, Christine E.</creator><creator>Gump, Dieter W.</creator><creator>Lahart, Christopher J.</creator><creator>Pandey, Janardan P.</creator><creator>Musher, Daniel M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>IgG Antibody to Pneumococcal Capsular Polysaccharide in Human Immunodeficiency Virus-Infected Subjects: Persistence of Antibody in Responders, Revaccination in Nonresponders, and Relationship of Immunoglobulin Allotype to Response</title><author>Rodriguez-Barradas, Maria C. ; Groover, Jean E. ; Lacke, Christine E. ; Gump, Dieter W. ; Lahart, Christopher J. ; Pandey, Janardan P. ; Musher, Daniel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-f6f54a5a14d96fad382741472b62ed9b8ea12c2faaed9bd8cc85d04942dbeb793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens, Bacterial</topic><topic>Bacterial Capsules - immunology</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>Dosage</topic><topic>HIV</topic><topic>HIV Infections - immunology</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunization, Secondary</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin allotypes</topic><topic>Immunoglobulin Allotypes - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Immunopathology</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal vaccine</topic><topic>Pneumococcal Vaccines</topic><topic>Polysaccharides</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Transponders</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez-Barradas, Maria C.</creatorcontrib><creatorcontrib>Groover, Jean E.</creatorcontrib><creatorcontrib>Lacke, Christine E.</creatorcontrib><creatorcontrib>Gump, Dieter W.</creatorcontrib><creatorcontrib>Lahart, Christopher J.</creatorcontrib><creatorcontrib>Pandey, Janardan P.</creatorcontrib><creatorcontrib>Musher, Daniel M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez-Barradas, Maria C.</au><au>Groover, Jean E.</au><au>Lacke, Christine E.</au><au>Gump, Dieter W.</au><au>Lahart, Christopher J.</au><au>Pandey, Janardan P.</au><au>Musher, Daniel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG Antibody to Pneumococcal Capsular Polysaccharide in Human Immunodeficiency Virus-Infected Subjects: Persistence of Antibody in Responders, Revaccination in Nonresponders, and Relationship of Immunoglobulin Allotype to Response</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>173</volume><issue>6</issue><spage>1347</spage><epage>1353</epage><pages>1347-1353</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ⩾1 µ/mL for ⩾3 of 5 PPS [high] or for ⩽1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ⩾1 µg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8648206</pmid><doi>10.1093/infdis/173.6.1347</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1996-06, Vol.173 (6), p.1347-1353 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult AIDS AIDS/HIV Antibodies Antibodies, Bacterial - blood Antigens, Bacterial Bacterial Capsules - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Biological and medical sciences Dosage HIV HIV Infections - immunology human immunodeficiency virus Humans Immunization Immunization Schedule Immunization, Secondary Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin allotypes Immunoglobulin Allotypes - blood Immunoglobulin G - blood Immunopathology Major Articles Male Medical sciences Middle Aged Pneumococcal Infections - prevention & control Pneumococcal vaccine Pneumococcal Vaccines Polysaccharides Streptococcus pneumoniae Streptococcus pneumoniae - immunology Transponders Vaccination |
| title | IgG Antibody to Pneumococcal Capsular Polysaccharide in Human Immunodeficiency Virus-Infected Subjects: Persistence of Antibody in Responders, Revaccination in Nonresponders, and Relationship of Immunoglobulin Allotype to Response |
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