Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors
To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma). Of the 38 histologically confirmed cases, 6 of 12 patients with primary or metastatic malignant tumor of...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1996-05, Vol.81 (5), p.1726-1729 |
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| creator | BENCSIK, Z SZABOLCS, I DOHAN, O SZILAGYI, G KOVACS, Z FERENCZ, A VÖRÖS, A KASZAS, I BOR, K GÖNGZI, J GOTH, M KOVACS, L |
| description | To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma). Of the 38 histologically confirmed cases, 6 of 12 patients with primary or metastatic malignant tumor of the adrenals and 7 of 14 patients with benign cortical adenoma had low DHEA-S levels. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate a benign adrenal tumor were 0.35, 0.50, and 0.60, and the values to indicate a cortical adenoma were 0.50, 0.67, and 0.47, respectively. Of the 14 cases of histologically confirmed benign cortical adenoma, 10 had signs of hormonal activity, but DHEA-S was suppressed in only 7 cases. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate clinically significant hormonal activity of a benign cortical adenoma were 0.60, 0.75, and 0.86, respectively. For comparison, 5 of 5 males and 2 of 5 females with metastatic carcinomatosis, but without involvement of the adrenals, also had low DHEA-S levels. The data clearly show that in nonselected cases of incidentaloma a suppressed DHEA-S level is not a good predictor of hormonal activity and that DHEA-S measurement may be valuable only after having ascertained the cortical origin and benign feature of the tumor. |
| doi_str_mv | 10.1210/jc.81.5.1726 |
| format | Article |
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Of the 38 histologically confirmed cases, 6 of 12 patients with primary or metastatic malignant tumor of the adrenals and 7 of 14 patients with benign cortical adenoma had low DHEA-S levels. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate a benign adrenal tumor were 0.35, 0.50, and 0.60, and the values to indicate a cortical adenoma were 0.50, 0.67, and 0.47, respectively. Of the 14 cases of histologically confirmed benign cortical adenoma, 10 had signs of hormonal activity, but DHEA-S was suppressed in only 7 cases. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate clinically significant hormonal activity of a benign cortical adenoma were 0.60, 0.75, and 0.86, respectively. For comparison, 5 of 5 males and 2 of 5 females with metastatic carcinomatosis, but without involvement of the adrenals, also had low DHEA-S levels. The data clearly show that in nonselected cases of incidentaloma a suppressed DHEA-S level is not a good predictor of hormonal activity and that DHEA-S measurement may be valuable only after having ascertained the cortical origin and benign feature of the tumor.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.81.5.1726</identifier><identifier>PMID: 8626824</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adenoma - blood ; Adolescent ; Adrenal Cortex Neoplasms - blood ; Adrenal Gland Neoplasms - blood ; Adrenal Gland Neoplasms - diagnosis ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Aged ; Aged, 80 and over ; Aldosterone - blood ; Biological and medical sciences ; Dehydroepiandrosterone - analogs & derivatives ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone Sulfate ; Diagnosis, Differential ; Endocrinopathies ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Renin - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 1996-05, Vol.81 (5), p.1726-1729</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-50ff837ae59811466cf5be63ba4ef4ad2173119e6bfa85678bbc4b10a2184aa53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3086486$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8626824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BENCSIK, Z</creatorcontrib><creatorcontrib>SZABOLCS, I</creatorcontrib><creatorcontrib>DOHAN, O</creatorcontrib><creatorcontrib>SZILAGYI, G</creatorcontrib><creatorcontrib>KOVACS, Z</creatorcontrib><creatorcontrib>FERENCZ, A</creatorcontrib><creatorcontrib>VÖRÖS, A</creatorcontrib><creatorcontrib>KASZAS, I</creatorcontrib><creatorcontrib>BOR, K</creatorcontrib><creatorcontrib>GÖNGZI, J</creatorcontrib><creatorcontrib>GOTH, M</creatorcontrib><creatorcontrib>KOVACS, L</creatorcontrib><title>Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma). Of the 38 histologically confirmed cases, 6 of 12 patients with primary or metastatic malignant tumor of the adrenals and 7 of 14 patients with benign cortical adenoma had low DHEA-S levels. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate a benign adrenal tumor were 0.35, 0.50, and 0.60, and the values to indicate a cortical adenoma were 0.50, 0.67, and 0.47, respectively. Of the 14 cases of histologically confirmed benign cortical adenoma, 10 had signs of hormonal activity, but DHEA-S was suppressed in only 7 cases. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate clinically significant hormonal activity of a benign cortical adenoma were 0.60, 0.75, and 0.86, respectively. For comparison, 5 of 5 males and 2 of 5 females with metastatic carcinomatosis, but without involvement of the adrenals, also had low DHEA-S levels. The data clearly show that in nonselected cases of incidentaloma a suppressed DHEA-S level is not a good predictor of hormonal activity and that DHEA-S measurement may be valuable only after having ascertained the cortical origin and benign feature of the tumor.</description><subject>Adenoma - blood</subject><subject>Adolescent</subject><subject>Adrenal Cortex Neoplasms - blood</subject><subject>Adrenal Gland Neoplasms - blood</subject><subject>Adrenal Gland Neoplasms - diagnosis</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aldosterone - blood</subject><subject>Biological and medical sciences</subject><subject>Dehydroepiandrosterone - analogs & derivatives</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone Sulfate</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Renin - blood</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUGLFDEUhIMo67h68yrkIKJgj0l3kk4fl3XXFQY8qOCteZ1-cTKkO2OS3mX-jT91M8ywp-JRH8WjipC3nK15zdmXnVlrvpZr3tbqGVnxTsiq5V37nKwYq3nVtfWfl-RVSjvGuBCyuSAXWtVK12JF_m_CAx1xexhjwL2DuWjKGMOMNC3eQkb68evdzVX18xP1eI-eukTnkCnQvyGMdB9xdCaHSIOl2xCnMIOnYLK7d_lA3VzgOaFHk7HQkB3OOdEHl7fFNG4sJ3h_KE_kEwNjxGNGXqYQ02vywoJP-Oasl-T37c2v67tq8-Pb9-urTWUaLnMlmbW6aQFlpzkXShkrB1TNAAKtgLHmbcN5h2qwoKVq9TAYMXAGNdcCQDaX5MMpdx_DvwVT7ieXDHoPM4Yl9a1mDZMtK-DnE2hKUymi7ffRTRAPPWf9cZB-Z3rNe9kfByn4u3PuMkw4PsHnBYr__uxDMuBthFJKesIappXQqnkEIkmWsg</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>BENCSIK, Z</creator><creator>SZABOLCS, I</creator><creator>DOHAN, O</creator><creator>SZILAGYI, G</creator><creator>KOVACS, Z</creator><creator>FERENCZ, A</creator><creator>VÖRÖS, A</creator><creator>KASZAS, I</creator><creator>BOR, K</creator><creator>GÖNGZI, J</creator><creator>GOTH, M</creator><creator>KOVACS, L</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors</title><author>BENCSIK, Z ; SZABOLCS, I ; DOHAN, O ; SZILAGYI, G ; KOVACS, Z ; FERENCZ, A ; VÖRÖS, A ; KASZAS, I ; BOR, K ; GÖNGZI, J ; GOTH, M ; KOVACS, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-50ff837ae59811466cf5be63ba4ef4ad2173119e6bfa85678bbc4b10a2184aa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenoma - blood</topic><topic>Adolescent</topic><topic>Adrenal Cortex Neoplasms - blood</topic><topic>Adrenal Gland Neoplasms - blood</topic><topic>Adrenal Gland Neoplasms - diagnosis</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aldosterone - blood</topic><topic>Biological and medical sciences</topic><topic>Dehydroepiandrosterone - analogs & derivatives</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dehydroepiandrosterone Sulfate</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Renin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BENCSIK, Z</creatorcontrib><creatorcontrib>SZABOLCS, I</creatorcontrib><creatorcontrib>DOHAN, O</creatorcontrib><creatorcontrib>SZILAGYI, G</creatorcontrib><creatorcontrib>KOVACS, Z</creatorcontrib><creatorcontrib>FERENCZ, A</creatorcontrib><creatorcontrib>VÖRÖS, A</creatorcontrib><creatorcontrib>KASZAS, I</creatorcontrib><creatorcontrib>BOR, K</creatorcontrib><creatorcontrib>GÖNGZI, J</creatorcontrib><creatorcontrib>GOTH, M</creatorcontrib><creatorcontrib>KOVACS, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BENCSIK, Z</au><au>SZABOLCS, I</au><au>DOHAN, O</au><au>SZILAGYI, G</au><au>KOVACS, Z</au><au>FERENCZ, A</au><au>VÖRÖS, A</au><au>KASZAS, I</au><au>BOR, K</au><au>GÖNGZI, J</au><au>GOTH, M</au><au>KOVACS, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>81</volume><issue>5</issue><spage>1726</spage><epage>1729</epage><pages>1726-1729</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma). Of the 38 histologically confirmed cases, 6 of 12 patients with primary or metastatic malignant tumor of the adrenals and 7 of 14 patients with benign cortical adenoma had low DHEA-S levels. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate a benign adrenal tumor were 0.35, 0.50, and 0.60, and the values to indicate a cortical adenoma were 0.50, 0.67, and 0.47, respectively. Of the 14 cases of histologically confirmed benign cortical adenoma, 10 had signs of hormonal activity, but DHEA-S was suppressed in only 7 cases. Thus, the sensitivity, specificity, and predictive value of a low DHEA-S level to indicate clinically significant hormonal activity of a benign cortical adenoma were 0.60, 0.75, and 0.86, respectively. For comparison, 5 of 5 males and 2 of 5 females with metastatic carcinomatosis, but without involvement of the adrenals, also had low DHEA-S levels. The data clearly show that in nonselected cases of incidentaloma a suppressed DHEA-S level is not a good predictor of hormonal activity and that DHEA-S measurement may be valuable only after having ascertained the cortical origin and benign feature of the tumor.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>8626824</pmid><doi>10.1210/jc.81.5.1726</doi><tpages>4</tpages></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 1996-05, Vol.81 (5), p.1726-1729 |
| issn | 0021-972X 1945-7197 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adenoma - blood Adolescent Adrenal Cortex Neoplasms - blood Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - diagnosis Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Aged Aged, 80 and over Aldosterone - blood Biological and medical sciences Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - blood Dehydroepiandrosterone Sulfate Diagnosis, Differential Endocrinopathies Female Humans Male Medical sciences Middle Aged Neoplasm Metastasis Non tumoral diseases. Target tissue resistance. Benign neoplasms Renin - blood |
| title | Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors |
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