Sexually dimorphic transcriptional responses to gonadotropin-releasing hormone require chronic in vivo exposure to estradiol

GnRH regulates secretion of the gonadotropins, LH and FSH, in a sexually dimorphic manner. In the present study, we examined GnRH regulation of the gonadotropin alpha-subunit promoter to assess whether sex-dependent hormonal effects are manifest at the transcriptional level. Primary cultures of male...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1996-06, Vol.137 (6), p.2300-2307
Hauptverfasser:	Colin, I M, Bauer-Dantoin, A C, Sundaresan, S, Kopp, P, Jameson, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Cells, Cultured Estradiol - administration & dosage Estradiol - pharmacology Estrogens Female Females Follicle-stimulating hormone Gene regulation Glycoprotein Hormones, alpha Subunit - genetics Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - pharmacology Gonadotropins Hormonal effects In vivo methods and tests Luciferases - genetics Luteinizing hormone Male Males Orchidectomy Orchiectomy Ovariectomy Pituitary Pituitary (anterior) Progesterone Promoter Regions, Genetic Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - metabolism Reporter gene Reproductive cycle Sex Characteristics Sex hormones Sexual dimorphism Stimulation Testosterone Transcription Transcription, Genetic - drug effects Transfection
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